Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets

Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidati...

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Autores principales:	Thembeka A. Nyawo, Carmen Pheiffer, Sithandiwe E. Mazibuko-Mbeje, Sinenhlanhla X. H. Mthembu, Tawanda M. Nyambuya, Bongani B. Nkambule, Hanél Sadie-Van Gijsen, Hans Strijdom, Luca Tiano, Phiwayinkosi V. Dludla
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epicardial adipose tissue oxidative stress inflammation cardiovascular disease exercise physical activity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a06f4cb666344b9589b25c6bb9b63d21
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spelling	oai:doaj.org-article:a06f4cb666344b9589b25c6bb9b63d212021-11-25T16:27:55ZPhysical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets10.3390/antiox101117582076-3921https://doaj.org/article/a06f4cb666344b9589b25c6bb9b63d212021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1758https://doaj.org/toc/2076-3921Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease.Thembeka A. NyawoCarmen PheifferSithandiwe E. Mazibuko-MbejeSinenhlanhla X. H. MthembuTawanda M. NyambuyaBongani B. NkambuleHanél Sadie-Van GijsenHans StrijdomLuca TianoPhiwayinkosi V. DludlaMDPI AGarticleepicardial adipose tissueoxidative stressinflammationcardiovascular diseaseexercisephysical activityTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1758, p 1758 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epicardial adipose tissue oxidative stress inflammation cardiovascular disease exercise physical activity Therapeutics. Pharmacology RM1-950
spellingShingle	epicardial adipose tissue oxidative stress inflammation cardiovascular disease exercise physical activity Therapeutics. Pharmacology RM1-950 Thembeka A. Nyawo Carmen Pheiffer Sithandiwe E. Mazibuko-Mbeje Sinenhlanhla X. H. Mthembu Tawanda M. Nyambuya Bongani B. Nkambule Hanél Sadie-Van Gijsen Hans Strijdom Luca Tiano Phiwayinkosi V. Dludla Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
description	Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease.
format	article
author	Thembeka A. Nyawo Carmen Pheiffer Sithandiwe E. Mazibuko-Mbeje Sinenhlanhla X. H. Mthembu Tawanda M. Nyambuya Bongani B. Nkambule Hanél Sadie-Van Gijsen Hans Strijdom Luca Tiano Phiwayinkosi V. Dludla
author_facet	Thembeka A. Nyawo Carmen Pheiffer Sithandiwe E. Mazibuko-Mbeje Sinenhlanhla X. H. Mthembu Tawanda M. Nyambuya Bongani B. Nkambule Hanél Sadie-Van Gijsen Hans Strijdom Luca Tiano Phiwayinkosi V. Dludla
author_sort	Thembeka A. Nyawo
title	Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
title_short	Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
title_full	Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
title_fullStr	Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
title_full_unstemmed	Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
title_sort	physical exercise potentially targets epicardial adipose tissue to reduce cardiovascular disease risk in patients with metabolic diseases: oxidative stress and inflammation emerge as major therapeutic targets
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a06f4cb666344b9589b25c6bb9b63d21
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Physical Exercise Potentially Targets Epicardial Adipose Tissue to Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases: Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets

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