Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action

Wamidh H Talib,1 Sonia A Al-hadid,1 Mai B Wild Ali,1 Intisar Hadi AL-Yasari,2 Mohammed R Abd Ali3 1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan; 2Food Technology Department, Faculty of Food Science, AL-Qasim Green University, Babylon, Iraq; 3Fac...

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Autores principales:	Talib WH, Al-hadid SA, Wild Ali MB, AL-Yasari IH, Abd Ali MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	natural products apoptosis p53 breast cancer Curcuma longa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a06f8a9e1766420ea5899b921bf0f692
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spelling	oai:doaj.org-article:a06f8a9e1766420ea5899b921bf0f6922021-12-02T08:05:38ZRole of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action1179-1314https://doaj.org/article/a06f8a9e1766420ea5899b921bf0f6922018-11-01T00:00:00Zhttps://www.dovepress.com/role-of-curcumin-in-regulating-p53-in-breast-cancer-an-overview-of-the-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Wamidh H Talib,1 Sonia A Al-hadid,1 Mai B Wild Ali,1 Intisar Hadi AL-Yasari,2 Mohammed R Abd Ali3 1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan; 2Food Technology Department, Faculty of Food Science, AL-Qasim Green University, Babylon, Iraq; 3Faculty of Nursing, University of Babylon, Babylon, Iraq Abstract: p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA repair, apoptosis, and cell cycle arrest. More than 50% of human cancers have a mutated nonfunctional p53. Breast cancer (BC) is one of the main causes of cancer-related deaths among females. p53 mutations in BC are associated with low survival rates and more resistance to the conventional therapies. Thus, targeting p53 activity was suggested as an important strategy in cancer therapy. During the past decades, cancer research was focused on the development of monotargeted anticancer therapies. However, the development of drug resistance by modulation of genes, proteins, and pathways was the main hindrance to the success of such therapies. Curcumin is a natural product, extracted from the roots of Curcuma longa, and possesses various biological effects including anticancer activity. Previous studies proved the ability of curcumin to modulate several signaling pathways and biomolecules in cancer. Safety and cost-effectiveness are additional inevitable advantages of curcumin. This review summarizes the effects of curcumin as a regulator of p53 in BC and the key molecular mechanisms of this regulation. Keywords: natural products, apoptosis, p53, breast cancer, Curcuma longaTalib WHAl-hadid SAWild Ali MBAL-Yasari IHAbd Ali MRDove Medical Pressarticlenatural productsapoptosisp53breast cancerCurcuma longaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 10, Pp 207-217 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural products apoptosis p53 breast cancer Curcuma longa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	natural products apoptosis p53 breast cancer Curcuma longa Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Talib WH Al-hadid SA Wild Ali MB AL-Yasari IH Abd Ali MR Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
description	Wamidh H Talib,1 Sonia A Al-hadid,1 Mai B Wild Ali,1 Intisar Hadi AL-Yasari,2 Mohammed R Abd Ali3 1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan; 2Food Technology Department, Faculty of Food Science, AL-Qasim Green University, Babylon, Iraq; 3Faculty of Nursing, University of Babylon, Babylon, Iraq Abstract: p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA repair, apoptosis, and cell cycle arrest. More than 50% of human cancers have a mutated nonfunctional p53. Breast cancer (BC) is one of the main causes of cancer-related deaths among females. p53 mutations in BC are associated with low survival rates and more resistance to the conventional therapies. Thus, targeting p53 activity was suggested as an important strategy in cancer therapy. During the past decades, cancer research was focused on the development of monotargeted anticancer therapies. However, the development of drug resistance by modulation of genes, proteins, and pathways was the main hindrance to the success of such therapies. Curcumin is a natural product, extracted from the roots of Curcuma longa, and possesses various biological effects including anticancer activity. Previous studies proved the ability of curcumin to modulate several signaling pathways and biomolecules in cancer. Safety and cost-effectiveness are additional inevitable advantages of curcumin. This review summarizes the effects of curcumin as a regulator of p53 in BC and the key molecular mechanisms of this regulation. Keywords: natural products, apoptosis, p53, breast cancer, Curcuma longa
format	article
author	Talib WH Al-hadid SA Wild Ali MB AL-Yasari IH Abd Ali MR
author_facet	Talib WH Al-hadid SA Wild Ali MB AL-Yasari IH Abd Ali MR
author_sort	Talib WH
title	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
title_short	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
title_full	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
title_fullStr	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
title_full_unstemmed	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
title_sort	role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a06f8a9e1766420ea5899b921bf0f692
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Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action

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