Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer

The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.

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Autores principales:	David Liu, Philip Abbosh, Daniel Keliher, Brendan Reardon, Diana Miao, Kent Mouw, Amaro Weiner-Taylor, Stephanie Wankowicz, Garam Han, Min Yuen Teo, Catharine Cipolla, Jaegil Kim, Gopa Iyer, Hikmat Al-Ahmadie, Essel Dulaimi, David Y. T. Chen, R. Katherine Alpaugh, Jean Hoffman-Censits, Levi A. Garraway, Gad Getz, Scott L. Carter, Joaquim Bellmunt, Elizabeth R. Plimack, Jonathan E. Rosenberg, Eliezer M. Van Allen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0719910fb0a4af896b5c3b5a29c89f7
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spelling	oai:doaj.org-article:a0719910fb0a4af896b5c3b5a29c89f72021-12-02T17:06:02ZMutational patterns in chemotherapy resistant muscle-invasive bladder cancer10.1038/s41467-017-02320-72041-1723https://doaj.org/article/a0719910fb0a4af896b5c3b5a29c89f72017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02320-7https://doaj.org/toc/2041-1723The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.David LiuPhilip AbboshDaniel KeliherBrendan ReardonDiana MiaoKent MouwAmaro Weiner-TaylorStephanie WankowiczGaram HanMin Yuen TeoCatharine CipollaJaegil KimGopa IyerHikmat Al-AhmadieEssel DulaimiDavid Y. T. ChenR. Katherine AlpaughJean Hoffman-CensitsLevi A. GarrawayGad GetzScott L. CarterJoaquim BellmuntElizabeth R. PlimackJonathan E. RosenbergEliezer M. Van AllenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Liu Philip Abbosh Daniel Keliher Brendan Reardon Diana Miao Kent Mouw Amaro Weiner-Taylor Stephanie Wankowicz Garam Han Min Yuen Teo Catharine Cipolla Jaegil Kim Gopa Iyer Hikmat Al-Ahmadie Essel Dulaimi David Y. T. Chen R. Katherine Alpaugh Jean Hoffman-Censits Levi A. Garraway Gad Getz Scott L. Carter Joaquim Bellmunt Elizabeth R. Plimack Jonathan E. Rosenberg Eliezer M. Van Allen Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
description	The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.
format	article
author	David Liu Philip Abbosh Daniel Keliher Brendan Reardon Diana Miao Kent Mouw Amaro Weiner-Taylor Stephanie Wankowicz Garam Han Min Yuen Teo Catharine Cipolla Jaegil Kim Gopa Iyer Hikmat Al-Ahmadie Essel Dulaimi David Y. T. Chen R. Katherine Alpaugh Jean Hoffman-Censits Levi A. Garraway Gad Getz Scott L. Carter Joaquim Bellmunt Elizabeth R. Plimack Jonathan E. Rosenberg Eliezer M. Van Allen
author_facet	David Liu Philip Abbosh Daniel Keliher Brendan Reardon Diana Miao Kent Mouw Amaro Weiner-Taylor Stephanie Wankowicz Garam Han Min Yuen Teo Catharine Cipolla Jaegil Kim Gopa Iyer Hikmat Al-Ahmadie Essel Dulaimi David Y. T. Chen R. Katherine Alpaugh Jean Hoffman-Censits Levi A. Garraway Gad Getz Scott L. Carter Joaquim Bellmunt Elizabeth R. Plimack Jonathan E. Rosenberg Eliezer M. Van Allen
author_sort	David Liu
title	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
title_short	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
title_full	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
title_fullStr	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
title_full_unstemmed	Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
title_sort	mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0719910fb0a4af896b5c3b5a29c89f7
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Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer

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