Identification and analysis of cation channel homologues in human pathogenic fungi.

Fungi are major causes of human, animal and plant disease. Human fungal infections can be fatal, but there are limited options for therapy, and resistance to commonly used anti-fungal drugs is widespread. The genomes of many fungi have recently been sequenced, allowing identification of proteins tha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David L Prole, Colin W Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a071c39ff82e44b6b0e17d1cb07da38a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a071c39ff82e44b6b0e17d1cb07da38a
record_format	dspace
spelling	oai:doaj.org-article:a071c39ff82e44b6b0e17d1cb07da38a2021-11-18T07:09:55ZIdentification and analysis of cation channel homologues in human pathogenic fungi.1932-620310.1371/journal.pone.0042404https://doaj.org/article/a071c39ff82e44b6b0e17d1cb07da38a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22876320/?tool=EBIhttps://doaj.org/toc/1932-6203Fungi are major causes of human, animal and plant disease. Human fungal infections can be fatal, but there are limited options for therapy, and resistance to commonly used anti-fungal drugs is widespread. The genomes of many fungi have recently been sequenced, allowing identification of proteins that may become targets for novel therapies. We examined the genomes of human fungal pathogens for genes encoding homologues of cation channels, which are prominent drug targets. Many of the fungal genomes examined contain genes encoding homologues of potassium (K(+)), calcium (Ca(2+)) and transient receptor potential (Trp) channels, but not sodium (Na(+)) channels or ligand-gated channels. Some fungal genomes contain multiple genes encoding homologues of K(+) and Trp channel subunits, and genes encoding novel homologues of voltage-gated K(v) channel subunits are found in Cryptococcus spp. Only a single gene encoding a homologue of a plasma membrane Ca(2+) channel was identified in the genome of each pathogenic fungus examined. These homologues are similar to the Cch1 Ca(2+) channel of Saccharomyces cerevisiae. The genomes of Aspergillus spp. and Cryptococcus spp., but not those of S. cerevisiae or the other pathogenic fungi examined, also encode homologues of the mitochondrial Ca(2+) uniporter (MCU). In contrast to humans, which express many K(+), Ca(2+) and Trp channels, the genomes of pathogenic fungi encode only very small numbers of K(+), Ca(2+) and Trp channel homologues. Furthermore, the sequences of fungal K(+), Ca(2+), Trp and MCU channels differ from those of human channels in regions that suggest differences in regulation and susceptibility to drugs.David L ProleColin W TaylorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42404 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David L Prole Colin W Taylor Identification and analysis of cation channel homologues in human pathogenic fungi.
description	Fungi are major causes of human, animal and plant disease. Human fungal infections can be fatal, but there are limited options for therapy, and resistance to commonly used anti-fungal drugs is widespread. The genomes of many fungi have recently been sequenced, allowing identification of proteins that may become targets for novel therapies. We examined the genomes of human fungal pathogens for genes encoding homologues of cation channels, which are prominent drug targets. Many of the fungal genomes examined contain genes encoding homologues of potassium (K(+)), calcium (Ca(2+)) and transient receptor potential (Trp) channels, but not sodium (Na(+)) channels or ligand-gated channels. Some fungal genomes contain multiple genes encoding homologues of K(+) and Trp channel subunits, and genes encoding novel homologues of voltage-gated K(v) channel subunits are found in Cryptococcus spp. Only a single gene encoding a homologue of a plasma membrane Ca(2+) channel was identified in the genome of each pathogenic fungus examined. These homologues are similar to the Cch1 Ca(2+) channel of Saccharomyces cerevisiae. The genomes of Aspergillus spp. and Cryptococcus spp., but not those of S. cerevisiae or the other pathogenic fungi examined, also encode homologues of the mitochondrial Ca(2+) uniporter (MCU). In contrast to humans, which express many K(+), Ca(2+) and Trp channels, the genomes of pathogenic fungi encode only very small numbers of K(+), Ca(2+) and Trp channel homologues. Furthermore, the sequences of fungal K(+), Ca(2+), Trp and MCU channels differ from those of human channels in regions that suggest differences in regulation and susceptibility to drugs.
format	article
author	David L Prole Colin W Taylor
author_facet	David L Prole Colin W Taylor
author_sort	David L Prole
title	Identification and analysis of cation channel homologues in human pathogenic fungi.
title_short	Identification and analysis of cation channel homologues in human pathogenic fungi.
title_full	Identification and analysis of cation channel homologues in human pathogenic fungi.
title_fullStr	Identification and analysis of cation channel homologues in human pathogenic fungi.
title_full_unstemmed	Identification and analysis of cation channel homologues in human pathogenic fungi.
title_sort	identification and analysis of cation channel homologues in human pathogenic fungi.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a071c39ff82e44b6b0e17d1cb07da38a
work_keys_str_mv	AT davidlprole identificationandanalysisofcationchannelhomologuesinhumanpathogenicfungi AT colinwtaylor identificationandanalysisofcationchannelhomologuesinhumanpathogenicfungi
_version_	1718423870782832640

Identification and analysis of cation channel homologues in human pathogenic fungi.

Ejemplares similares