Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis

Abstract Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ability of niacin to modulate angiogene...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hesham Aly Salem, Walaa Wadie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0720cb9ec47465e9f21210a7e9ad770
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0720cb9ec47465e9f21210a7e9ad770
record_format	dspace
spelling	oai:doaj.org-article:a0720cb9ec47465e9f21210a7e9ad7702021-12-02T11:52:56ZEffect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis10.1038/s41598-017-07280-y2045-2322https://doaj.org/article/a0720cb9ec47465e9f21210a7e9ad7702017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07280-yhttps://doaj.org/toc/2045-2322Abstract Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ability of niacin to modulate angiogenesis which plays a crucial role of in the pathogenesis of inflammatory bowel disease. Rats were given niacin for 2 weeks. On day 8, colitis was induced by intrarectal administration of iodoacetamide. Rats were sacrificed on day 15 and colonic damage was assessed macroscopically and histologically. Colonic myeloperoxidase (MPO), tumour necrosis factor (TNF)-α, interleukin (IL)-10, vascular endothelial growth factor (VEGF), angiostatin and endostatin levels were determined. Niacin attenuated the severity of colitis as demonstrated by a decrease in weight loss, colonic wet weight and MPO activity. Iodoacetamide-induced rise in the colonic levels of TNF-α, VEGF, angiostatin and endostatin was reversed by niacin. Moreover, niacin normalized IL-10 level in colon. Mepenzolate bromide, a GPR109A receptor blocker, abolished the beneficial effects of niacin on body weight, colon wet weight as well as colonic levels of MPO and VEGF. Therefore, niacin was effective against iodoacetamide-induced colitis through ameliorating pathologic angiogenesis and inflammatory changes in a GPR109A-dependent manner.Hesham Aly SalemWalaa WadieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hesham Aly Salem Walaa Wadie Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
description	Abstract Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ability of niacin to modulate angiogenesis which plays a crucial role of in the pathogenesis of inflammatory bowel disease. Rats were given niacin for 2 weeks. On day 8, colitis was induced by intrarectal administration of iodoacetamide. Rats were sacrificed on day 15 and colonic damage was assessed macroscopically and histologically. Colonic myeloperoxidase (MPO), tumour necrosis factor (TNF)-α, interleukin (IL)-10, vascular endothelial growth factor (VEGF), angiostatin and endostatin levels were determined. Niacin attenuated the severity of colitis as demonstrated by a decrease in weight loss, colonic wet weight and MPO activity. Iodoacetamide-induced rise in the colonic levels of TNF-α, VEGF, angiostatin and endostatin was reversed by niacin. Moreover, niacin normalized IL-10 level in colon. Mepenzolate bromide, a GPR109A receptor blocker, abolished the beneficial effects of niacin on body weight, colon wet weight as well as colonic levels of MPO and VEGF. Therefore, niacin was effective against iodoacetamide-induced colitis through ameliorating pathologic angiogenesis and inflammatory changes in a GPR109A-dependent manner.
format	article
author	Hesham Aly Salem Walaa Wadie
author_facet	Hesham Aly Salem Walaa Wadie
author_sort	Hesham Aly Salem
title	Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
title_short	Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
title_full	Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
title_fullStr	Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
title_full_unstemmed	Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis
title_sort	effect of niacin on inflammation and angiogenesis in a murine model of ulcerative colitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0720cb9ec47465e9f21210a7e9ad770
work_keys_str_mv	AT heshamalysalem effectofniacinoninflammationandangiogenesisinamurinemodelofulcerativecolitis AT walaawadie effectofniacinoninflammationandangiogenesisinamurinemodelofulcerativecolitis
_version_	1718394942003347456

Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis

Ejemplares similares