Malignant neoplasm of the bronchi and lung: Russian clinical guidelines

Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacc...

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Autores principales:	Konstantin K. Laktionov, Elena V. Artamonova, Tatiana N. Borisova, Valerii V. Breder, Iurii M. Bychkov, Liubov Iu. Vladimirova, Nikita M. Volkov, Stepan M. Ergnian, Albina S. Zhabina, Pavel V. Kononets, Aleksandr E. Kuz’minov, Evgenii V. Levchenko, Olga A. Malikhova, Dimitr T. Marinov, Sergei V. Miller, Fedor V. Moiseenko, Valeriia V. Mochal’nikova, Sergei N. Novikov, Oleg V. Pikin, Elena V. Reutova, Evgenii O. Rodionov, Dina D. Sakaeva, Anna I. Semenova, Aleksei V. Smolin, Vladimir M. Sotnikov, Sergei A. Tuzikov, Igor N. Turkin, Igor E. Tiurin, Vladimir D. Chkhikvadze, Konstantin I. Kolbanov, Andrei V. Chernichenko, Aleksandr A. Fedenko, Elena V. Filonenko, Aleksei A. Nevol’skikh, Sergei A. Ivanov, Zhanna V. Khailova, Tigran G. Gevorkian, Aleksei V. Butenko, Ilmira R. Gil’mutdinova, Irina V. Gridneva, Mikhail A. Eremushkin, Margarita A. Zernova, Boris S. Kasparov, Denis V. Kovlen, Kristina O. Kondrat’eva, Tatiana V. Konchugova, Svetlana B. Korotkova, Anton A. Krutov, Olga A. Obukhova, Gennadii N. Ponomarenko, Tatiana Iu. Semiglazova, Aleksandra M. Stepanova, Galina A. Tkachenko, Marina M. Khulamkhanova
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	lung cancer clinical guidelines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a0745ce3a3d34da8b1d40865cb268cd1
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spelling	oai:doaj.org-article:a0745ce3a3d34da8b1d40865cb268cd12021-11-30T16:55:01ZMalignant neoplasm of the bronchi and lung: Russian clinical guidelines1815-14341815-144210.26442/18151434.2021.3.201048https://doaj.org/article/a0745ce3a3d34da8b1d40865cb268cd12021-11-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/87960/66096https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.Konstantin K. LaktionovElena V. ArtamonovaTatiana N. BorisovaValerii V. BrederIurii M. BychkovLiubov Iu. VladimirovaNikita M. VolkovStepan M. ErgnianAlbina S. ZhabinaPavel V. KononetsAleksandr E. Kuz’minovEvgenii V. LevchenkoOlga A. MalikhovaDimitr T. MarinovSergei V. MillerFedor V. MoiseenkoValeriia V. Mochal’nikovaSergei N. NovikovOleg V. PikinElena V. ReutovaEvgenii O. RodionovDina D. SakaevaAnna I. SemenovaAleksei V. SmolinVladimir M. SotnikovSergei A. TuzikovIgor N. TurkinIgor E. TiurinVladimir D. ChkhikvadzeKonstantin I. KolbanovAndrei V. ChernichenkoAleksandr A. FedenkoElena V. FilonenkoAleksei A. Nevol’skikhSergei A. IvanovZhanna V. KhailovaTigran G. GevorkianAleksei V. ButenkoIlmira R. Gil’mutdinovaIrina V. GridnevaMikhail A. EremushkinMargarita A. ZernovaBoris S. KasparovDenis V. KovlenKristina O. Kondrat’evaTatiana V. KonchugovaSvetlana B. KorotkovaAnton A. KrutovOlga A. ObukhovaGennadii N. PonomarenkoTatiana Iu. SemiglazovaAleksandra M. StepanovaGalina A. TkachenkoMarina M. KhulamkhanovaIP Habib O.N.articlelung cancerclinical guidelinesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 3, Pp 369-402 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	lung cancer clinical guidelines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lung cancer clinical guidelines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Konstantin K. Laktionov Elena V. Artamonova Tatiana N. Borisova Valerii V. Breder Iurii M. Bychkov Liubov Iu. Vladimirova Nikita M. Volkov Stepan M. Ergnian Albina S. Zhabina Pavel V. Kononets Aleksandr E. Kuz’minov Evgenii V. Levchenko Olga A. Malikhova Dimitr T. Marinov Sergei V. Miller Fedor V. Moiseenko Valeriia V. Mochal’nikova Sergei N. Novikov Oleg V. Pikin Elena V. Reutova Evgenii O. Rodionov Dina D. Sakaeva Anna I. Semenova Aleksei V. Smolin Vladimir M. Sotnikov Sergei A. Tuzikov Igor N. Turkin Igor E. Tiurin Vladimir D. Chkhikvadze Konstantin I. Kolbanov Andrei V. Chernichenko Aleksandr A. Fedenko Elena V. Filonenko Aleksei A. Nevol’skikh Sergei A. Ivanov Zhanna V. Khailova Tigran G. Gevorkian Aleksei V. Butenko Ilmira R. Gil’mutdinova Irina V. Gridneva Mikhail A. Eremushkin Margarita A. Zernova Boris S. Kasparov Denis V. Kovlen Kristina O. Kondrat’eva Tatiana V. Konchugova Svetlana B. Korotkova Anton A. Krutov Olga A. Obukhova Gennadii N. Ponomarenko Tatiana Iu. Semiglazova Aleksandra M. Stepanova Galina A. Tkachenko Marina M. Khulamkhanova Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
description	Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.
format	article
author	Konstantin K. Laktionov Elena V. Artamonova Tatiana N. Borisova Valerii V. Breder Iurii M. Bychkov Liubov Iu. Vladimirova Nikita M. Volkov Stepan M. Ergnian Albina S. Zhabina Pavel V. Kononets Aleksandr E. Kuz’minov Evgenii V. Levchenko Olga A. Malikhova Dimitr T. Marinov Sergei V. Miller Fedor V. Moiseenko Valeriia V. Mochal’nikova Sergei N. Novikov Oleg V. Pikin Elena V. Reutova Evgenii O. Rodionov Dina D. Sakaeva Anna I. Semenova Aleksei V. Smolin Vladimir M. Sotnikov Sergei A. Tuzikov Igor N. Turkin Igor E. Tiurin Vladimir D. Chkhikvadze Konstantin I. Kolbanov Andrei V. Chernichenko Aleksandr A. Fedenko Elena V. Filonenko Aleksei A. Nevol’skikh Sergei A. Ivanov Zhanna V. Khailova Tigran G. Gevorkian Aleksei V. Butenko Ilmira R. Gil’mutdinova Irina V. Gridneva Mikhail A. Eremushkin Margarita A. Zernova Boris S. Kasparov Denis V. Kovlen Kristina O. Kondrat’eva Tatiana V. Konchugova Svetlana B. Korotkova Anton A. Krutov Olga A. Obukhova Gennadii N. Ponomarenko Tatiana Iu. Semiglazova Aleksandra M. Stepanova Galina A. Tkachenko Marina M. Khulamkhanova
author_facet	Konstantin K. Laktionov Elena V. Artamonova Tatiana N. Borisova Valerii V. Breder Iurii M. Bychkov Liubov Iu. Vladimirova Nikita M. Volkov Stepan M. Ergnian Albina S. Zhabina Pavel V. Kononets Aleksandr E. Kuz’minov Evgenii V. Levchenko Olga A. Malikhova Dimitr T. Marinov Sergei V. Miller Fedor V. Moiseenko Valeriia V. Mochal’nikova Sergei N. Novikov Oleg V. Pikin Elena V. Reutova Evgenii O. Rodionov Dina D. Sakaeva Anna I. Semenova Aleksei V. Smolin Vladimir M. Sotnikov Sergei A. Tuzikov Igor N. Turkin Igor E. Tiurin Vladimir D. Chkhikvadze Konstantin I. Kolbanov Andrei V. Chernichenko Aleksandr A. Fedenko Elena V. Filonenko Aleksei A. Nevol’skikh Sergei A. Ivanov Zhanna V. Khailova Tigran G. Gevorkian Aleksei V. Butenko Ilmira R. Gil’mutdinova Irina V. Gridneva Mikhail A. Eremushkin Margarita A. Zernova Boris S. Kasparov Denis V. Kovlen Kristina O. Kondrat’eva Tatiana V. Konchugova Svetlana B. Korotkova Anton A. Krutov Olga A. Obukhova Gennadii N. Ponomarenko Tatiana Iu. Semiglazova Aleksandra M. Stepanova Galina A. Tkachenko Marina M. Khulamkhanova
author_sort	Konstantin K. Laktionov
title	Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
title_short	Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
title_full	Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
title_fullStr	Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
title_full_unstemmed	Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
title_sort	malignant neoplasm of the bronchi and lung: russian clinical guidelines
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/a0745ce3a3d34da8b1d40865cb268cd1
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Malignant neoplasm of the bronchi and lung: Russian clinical guidelines

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