Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study

Abstract Chronic obstructive pulmonary disease (COPD) is a complex disease that is predicted to be the third most common cause of death by 2030. In Canada, the care and management of chronic conditions is largely provided by primary care providers. Although there is emerging research and initiatives...

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Autores principales:	Andrew Cave, Anh Pham, Cliff Lindeman, Boglarka Soos, Tyler Williamson, Neil Drummond
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/a078037a59684fa1932f1b6809dc1c85
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spelling	oai:doaj.org-article:a078037a59684fa1932f1b6809dc1c852021-12-02T18:02:43ZChronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study10.1038/s41533-021-00249-52055-1010https://doaj.org/article/a078037a59684fa1932f1b6809dc1c852021-06-01T00:00:00Zhttps://doi.org/10.1038/s41533-021-00249-5https://doaj.org/toc/2055-1010Abstract Chronic obstructive pulmonary disease (COPD) is a complex disease that is predicted to be the third most common cause of death by 2030. In Canada, the care and management of chronic conditions is largely provided by primary care providers. Although there is emerging research and initiatives that describe the prevalence of COPD in Canadian primary care settings, to our knowledge, there have been no efforts to use a large pan-Canadian database to analyze COPD as a risk factor for other common chronic conditions managed in primary care. We report the risk of developing comorbidities after the onset of COPD, that is, the extent to which COPD is a risk factor for developing common chronic conditions (heart failure, depression, anxiety, coronary artery disease, diabetes, anemia, hypertension, ischemic heart disease, underweight, and osteoporosis). After adjusting for age, sex, urban vs rural residence, and smoking status, the relative risks for patients with COPD at baseline were significantly higher for subsequent incidence of anemia, anxiety, diabetes, depression, heart failure, ischemic heart disease, lung cancer, osteoporosis, sleep apnea, underweight, and hypertension than patients without COPD. Using a cut-point of a 200% increase in relative risk as indicative of particular clinical relevance, COPD has a statistically and clinically significant association with developing lung cancer, becoming underweight, and developing heart failure.Andrew CaveAnh PhamCliff LindemanBoglarka SoosTyler WilliamsonNeil DrummondNature PortfolioarticleDiseases of the respiratory systemRC705-779ENnpj Primary Care Respiratory Medicine, Vol 31, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Andrew Cave Anh Pham Cliff Lindeman Boglarka Soos Tyler Williamson Neil Drummond Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
description	Abstract Chronic obstructive pulmonary disease (COPD) is a complex disease that is predicted to be the third most common cause of death by 2030. In Canada, the care and management of chronic conditions is largely provided by primary care providers. Although there is emerging research and initiatives that describe the prevalence of COPD in Canadian primary care settings, to our knowledge, there have been no efforts to use a large pan-Canadian database to analyze COPD as a risk factor for other common chronic conditions managed in primary care. We report the risk of developing comorbidities after the onset of COPD, that is, the extent to which COPD is a risk factor for developing common chronic conditions (heart failure, depression, anxiety, coronary artery disease, diabetes, anemia, hypertension, ischemic heart disease, underweight, and osteoporosis). After adjusting for age, sex, urban vs rural residence, and smoking status, the relative risks for patients with COPD at baseline were significantly higher for subsequent incidence of anemia, anxiety, diabetes, depression, heart failure, ischemic heart disease, lung cancer, osteoporosis, sleep apnea, underweight, and hypertension than patients without COPD. Using a cut-point of a 200% increase in relative risk as indicative of particular clinical relevance, COPD has a statistically and clinically significant association with developing lung cancer, becoming underweight, and developing heart failure.
format	article
author	Andrew Cave Anh Pham Cliff Lindeman Boglarka Soos Tyler Williamson Neil Drummond
author_facet	Andrew Cave Anh Pham Cliff Lindeman Boglarka Soos Tyler Williamson Neil Drummond
author_sort	Andrew Cave
title	Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
title_short	Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
title_full	Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
title_fullStr	Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
title_full_unstemmed	Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study
title_sort	chronic obstructive pulmonary disease as a risk factor in primary care: a canadian retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a078037a59684fa1932f1b6809dc1c85
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Chronic obstructive pulmonary disease as a risk factor in primary care: a Canadian retrospective cohort study

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