Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia

Abstract Although it is known that ambient temperature can affect the diagnostic performance of the fecal immunochemical test (FIT), the impact of other weather parameters, including humidity, on the sensitivity of FIT remains to be further investigated. We aimed to evaluate the impact of ambient te...

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Autores principales:	Chan Hyuk Park, Yoon Suk Jung, Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a07849c381f9446881a2d961a3697947
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spelling	oai:doaj.org-article:a07849c381f9446881a2d961a36979472021-12-02T15:08:47ZImpact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia10.1038/s41598-019-44490-y2045-2322https://doaj.org/article/a07849c381f9446881a2d961a36979472019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-44490-yhttps://doaj.org/toc/2045-2322Abstract Although it is known that ambient temperature can affect the diagnostic performance of the fecal immunochemical test (FIT), the impact of other weather parameters, including humidity, on the sensitivity of FIT remains to be further investigated. We aimed to evaluate the impact of ambient temperature and humidity on the performance of FIT for screening for advanced colorectal neoplasia (ACRN). We included asymptomatic individuals who had undergone both screening colonoscopy and FIT. The diagnostic performance of FIT, including its sensitivity, was analyzed according to the ambient temperature and humidity on the day that FIT was performed. Temperature and humidity were divided into five levels. Among 35,461 participants, 589 (1.7%) had ACRN. The positivity rate of FIT was lower at ≥24 °C (3.1%) than at <0 °C (3.9%), 0–8 °C (4.3%), and 8–16 °C (3.9%). It was also lower at 80–90% humidity (3.1%) than at < 60% humidity (3.9%). Multivariable analysis showed that high ambient temperature (≥24 °C) with high ambient humidity (≥80%) was associated with a low positivity rate of FIT (odds ratio [OR] 0.62, 95% confidence interval [CI] 0.44–0.86). Sensitivity tended to decrease at high ambient temperature (<24 °C vs. ≥24 °C; 20.8% vs. 14.6%, P = 0.110) and was significantly lower at high ambient humidity (<80% vs. ≥80%; 21.0% vs. 12.5%, P = 0.044). The multivariable analysis also showed that high ambient humidity was independently associated with low sensitivity of FIT (OR 0.54, 95% CI 0.28–0.96). In conclusion, high ambient humidity decreased the sensitivity, while high ambient temperature along with high ambient humidity decreased the positivity rate of FIT.Chan Hyuk ParkYoon Suk JungNam Hee KimMi Yeon LeeJung Ho ParkDong Il ParkChong Il SohnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chan Hyuk Park Yoon Suk Jung Nam Hee Kim Mi Yeon Lee Jung Ho Park Dong Il Park Chong Il Sohn Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
description	Abstract Although it is known that ambient temperature can affect the diagnostic performance of the fecal immunochemical test (FIT), the impact of other weather parameters, including humidity, on the sensitivity of FIT remains to be further investigated. We aimed to evaluate the impact of ambient temperature and humidity on the performance of FIT for screening for advanced colorectal neoplasia (ACRN). We included asymptomatic individuals who had undergone both screening colonoscopy and FIT. The diagnostic performance of FIT, including its sensitivity, was analyzed according to the ambient temperature and humidity on the day that FIT was performed. Temperature and humidity were divided into five levels. Among 35,461 participants, 589 (1.7%) had ACRN. The positivity rate of FIT was lower at ≥24 °C (3.1%) than at <0 °C (3.9%), 0–8 °C (4.3%), and 8–16 °C (3.9%). It was also lower at 80–90% humidity (3.1%) than at < 60% humidity (3.9%). Multivariable analysis showed that high ambient temperature (≥24 °C) with high ambient humidity (≥80%) was associated with a low positivity rate of FIT (odds ratio [OR] 0.62, 95% confidence interval [CI] 0.44–0.86). Sensitivity tended to decrease at high ambient temperature (<24 °C vs. ≥24 °C; 20.8% vs. 14.6%, P = 0.110) and was significantly lower at high ambient humidity (<80% vs. ≥80%; 21.0% vs. 12.5%, P = 0.044). The multivariable analysis also showed that high ambient humidity was independently associated with low sensitivity of FIT (OR 0.54, 95% CI 0.28–0.96). In conclusion, high ambient humidity decreased the sensitivity, while high ambient temperature along with high ambient humidity decreased the positivity rate of FIT.
format	article
author	Chan Hyuk Park Yoon Suk Jung Nam Hee Kim Mi Yeon Lee Jung Ho Park Dong Il Park Chong Il Sohn
author_facet	Chan Hyuk Park Yoon Suk Jung Nam Hee Kim Mi Yeon Lee Jung Ho Park Dong Il Park Chong Il Sohn
author_sort	Chan Hyuk Park
title	Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
title_short	Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
title_full	Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
title_fullStr	Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
title_full_unstemmed	Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
title_sort	impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a07849c381f9446881a2d961a3697947
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Impact of temperature and humidity on performance of the fecal immunochemical test for advanced colorectal neoplasia

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