Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?

ABSTRACT The human gastrointestinal tract harbors a diverse, highly mutualistic microbial flora which could produce a myriad of specialized metabolites. These specialized metabolites are the chemical cellphones that gut microflora use to communicate with their human host and could potentially be use...

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Autores principales:	Qiang Lyu, Cheng-Chih Hsu
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	GNPS gut microbiome liquid chromatography mass spectrometry metabolome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a07c06bab83346ecabd57e986c2c2bf4
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spelling	oai:doaj.org-article:a07c06bab83346ecabd57e986c2c2bf42021-12-02T19:46:20ZCan Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?10.1128/mSystems.00187-172379-5077https://doaj.org/article/a07c06bab83346ecabd57e986c2c2bf42018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00187-17https://doaj.org/toc/2379-5077ABSTRACT The human gastrointestinal tract harbors a diverse, highly mutualistic microbial flora which could produce a myriad of specialized metabolites. These specialized metabolites are the chemical cellphones that gut microflora use to communicate with their human host and could potentially be used to cure diseases. Chemical compounds in diet also shape the gut flora. In order to understand which and how the gut microbe-derived specialized metabolites affect human health, the “gut microbiome-metabolomic-human health axis” is thus proposed. In our laboratory, a strategy combining genomic, chemical, phenotypical analyses has been implemented to mine the treasures of bioactive molecules found in our gut and stool. We believe that the cutting edge metabolomics will bridge microbiology and human health.Qiang LyuCheng-Chih HsuAmerican Society for MicrobiologyarticleGNPSgut microbiomeliquid chromatography mass spectrometrymetabolomeMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	GNPS gut microbiome liquid chromatography mass spectrometry metabolome Microbiology QR1-502
spellingShingle	GNPS gut microbiome liquid chromatography mass spectrometry metabolome Microbiology QR1-502 Qiang Lyu Cheng-Chih Hsu Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
description	ABSTRACT The human gastrointestinal tract harbors a diverse, highly mutualistic microbial flora which could produce a myriad of specialized metabolites. These specialized metabolites are the chemical cellphones that gut microflora use to communicate with their human host and could potentially be used to cure diseases. Chemical compounds in diet also shape the gut flora. In order to understand which and how the gut microbe-derived specialized metabolites affect human health, the “gut microbiome-metabolomic-human health axis” is thus proposed. In our laboratory, a strategy combining genomic, chemical, phenotypical analyses has been implemented to mine the treasures of bioactive molecules found in our gut and stool. We believe that the cutting edge metabolomics will bridge microbiology and human health.
format	article
author	Qiang Lyu Cheng-Chih Hsu
author_facet	Qiang Lyu Cheng-Chih Hsu
author_sort	Qiang Lyu
title	Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
title_short	Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
title_full	Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
title_fullStr	Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
title_full_unstemmed	Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?
title_sort	can diet influence our health by altering intestinal microbiota-derived fecal metabolites?
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/a07c06bab83346ecabd57e986c2c2bf4
work_keys_str_mv	AT qianglyu candietinfluenceourhealthbyalteringintestinalmicrobiotaderivedfecalmetabolites AT chengchihhsu candietinfluenceourhealthbyalteringintestinalmicrobiotaderivedfecalmetabolites
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Can Diet Influence Our Health by Altering Intestinal Microbiota-Derived Fecal Metabolites?

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