Antidepressant therapy in complex treatment of painful diabetic polyneuropathy

Aims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lidia Grigor'evna Turbina, Sergey Alexandrovich Gordeev, Anna Aronovna Zus'man
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	diabetic polyneuropathy neuropathic pain anxiety depression venlafaxine pipofezine carbamazepine Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/a07cf4cbcb9e484995ebefa677e678f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a07cf4cbcb9e484995ebefa677e678f8
record_format	dspace
spelling	oai:doaj.org-article:a07cf4cbcb9e484995ebefa677e678f82021-11-14T09:00:17ZAntidepressant therapy in complex treatment of painful diabetic polyneuropathy2072-03512072-037810.14341/2072-0351-6088https://doaj.org/article/a07cf4cbcb9e484995ebefa677e678f82012-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6088https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21 male and 27 female patients with painful DP (mean age 54.3?14.2 years; mean duration ofdiabetes mellitus (DM) 8.9?5.1 years; mean duration of DP - 3.8?2.1 years). DP was diagnosed clinically and by electromyographymethod. Pain syndrome was assessed with DN4 questionnaire, visual analogue scale (VAS) and McGill Pain Questionnaire. Psycho-vegetative status was evaluated by Spielberger test with reactive and personal anxiety (RA and PA) assessment and Beck depressioninventory. All patients received symptomatic pharmacotherapy with anticonvulsant and antidepressant agent. First group (DP-1)included 23 patients on carbamazepin and pipofezine. Second group (DP-2) included 25 patients on carbamazepin and venlafaxine. Results. Following treatment, pain syndrome was completely compensated in 8.7% of patients from DP-1 group and 12.5% from DP-2.Decrease in pain intensity?50% from initial level was achieved in 73.9% (DP-1) and 75% (DP-2) of cases. Mean pain intensityaccording to VAS reduced from 5.2?2.1 points to 2.3?1.4 points (DP-1) and from 5.8?2.3 points (DP-2) with equal statistical significance(pLidia Grigor'evna TurbinaSergey Alexandrovich GordeevAnna Aronovna Zus'manEndocrinology Research Centrearticlediabetic polyneuropathyneuropathic painanxietydepressionvenlafaxinepipofezinecarbamazepineNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 3, Pp 67-73 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic polyneuropathy neuropathic pain anxiety depression venlafaxine pipofezine carbamazepine Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic polyneuropathy neuropathic pain anxiety depression venlafaxine pipofezine carbamazepine Nutritional diseases. Deficiency diseases RC620-627 Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
description	Aims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21 male and 27 female patients with painful DP (mean age 54.3?14.2 years; mean duration ofdiabetes mellitus (DM) 8.9?5.1 years; mean duration of DP - 3.8?2.1 years). DP was diagnosed clinically and by electromyographymethod. Pain syndrome was assessed with DN4 questionnaire, visual analogue scale (VAS) and McGill Pain Questionnaire. Psycho-vegetative status was evaluated by Spielberger test with reactive and personal anxiety (RA and PA) assessment and Beck depressioninventory. All patients received symptomatic pharmacotherapy with anticonvulsant and antidepressant agent. First group (DP-1)included 23 patients on carbamazepin and pipofezine. Second group (DP-2) included 25 patients on carbamazepin and venlafaxine. Results. Following treatment, pain syndrome was completely compensated in 8.7% of patients from DP-1 group and 12.5% from DP-2.Decrease in pain intensity?50% from initial level was achieved in 73.9% (DP-1) and 75% (DP-2) of cases. Mean pain intensityaccording to VAS reduced from 5.2?2.1 points to 2.3?1.4 points (DP-1) and from 5.8?2.3 points (DP-2) with equal statistical significance(p
format	article
author	Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man
author_facet	Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man
author_sort	Lidia Grigor'evna Turbina
title	Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
title_short	Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
title_full	Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
title_fullStr	Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
title_full_unstemmed	Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
title_sort	antidepressant therapy in complex treatment of painful diabetic polyneuropathy
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/a07cf4cbcb9e484995ebefa677e678f8
work_keys_str_mv	AT lidiagrigorevnaturbina antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy AT sergeyalexandrovichgordeev antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy AT annaaronovnazusman antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy
_version_	1718429599432441856

Antidepressant therapy in complex treatment of painful diabetic polyneuropathy

Ejemplares similares