Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

Cell extrusion regulates monolayer cell density and is critical in maintaining epithelia integrity, which has implications in homeostasis, development, and cancer progression. Here the authors describe how monolayer integrate mechanical signals from tissue mechanics, cell-cell adhesion, cell-substra...

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Autores principales:	Anh Phuong Le, Jean-François Rupprecht, René-Marc Mège, Yusuke Toyama, Chwee Teck Lim, Benoît Ladoux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a07d2004be3d4a2ca1efcb70f4282ac2
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spelling	oai:doaj.org-article:a07d2004be3d4a2ca1efcb70f4282ac22021-12-02T15:22:48ZAdhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion10.1038/s41467-020-20563-92041-1723https://doaj.org/article/a07d2004be3d4a2ca1efcb70f4282ac22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20563-9https://doaj.org/toc/2041-1723Cell extrusion regulates monolayer cell density and is critical in maintaining epithelia integrity, which has implications in homeostasis, development, and cancer progression. Here the authors describe how monolayer integrate mechanical signals from tissue mechanics, cell-cell adhesion, cell-substrate adhesion and cytoskeleton coordinate cell extrusion.Anh Phuong LeJean-François RupprechtRené-Marc MègeYusuke ToyamaChwee Teck LimBenoît LadouxNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anh Phuong Le Jean-François Rupprecht René-Marc Mège Yusuke Toyama Chwee Teck Lim Benoît Ladoux Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
description	Cell extrusion regulates monolayer cell density and is critical in maintaining epithelia integrity, which has implications in homeostasis, development, and cancer progression. Here the authors describe how monolayer integrate mechanical signals from tissue mechanics, cell-cell adhesion, cell-substrate adhesion and cytoskeleton coordinate cell extrusion.
format	article
author	Anh Phuong Le Jean-François Rupprecht René-Marc Mège Yusuke Toyama Chwee Teck Lim Benoît Ladoux
author_facet	Anh Phuong Le Jean-François Rupprecht René-Marc Mège Yusuke Toyama Chwee Teck Lim Benoît Ladoux
author_sort	Anh Phuong Le
title	Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
title_short	Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
title_full	Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
title_fullStr	Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
title_full_unstemmed	Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
title_sort	adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a07d2004be3d4a2ca1efcb70f4282ac2
work_keys_str_mv	AT anhphuongle adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion AT jeanfrancoisrupprecht adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion AT renemarcmege adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion AT yusuketoyama adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion AT chweetecklim adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion AT benoitladoux adhesionmediatedheterogeneousactinorganizationgovernsapoptoticcellextrusion
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Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

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