Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila.

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Autores principales:	Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan, Marc R. Freeman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0803d1cf18d4b59932815bc571bcf90
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spelling	oai:doaj.org-article:a0803d1cf18d4b59932815bc571bcf902021-12-02T14:40:26ZAxon degeneration induces glial responses through Draper-TRAF4-JNK signalling10.1038/ncomms143552041-1723https://doaj.org/article/a0803d1cf18d4b59932815bc571bcf902017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14355https://doaj.org/toc/2041-1723The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila.Tsai-Yi LuJennifer M. MacDonaldLukas J. NeukommAmy E. SheehanRachel BradshawMary A. LoganMarc R. FreemanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tsai-Yi Lu Jennifer M. MacDonald Lukas J. Neukomm Amy E. Sheehan Rachel Bradshaw Mary A. Logan Marc R. Freeman Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
description	The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila.
format	article
author	Tsai-Yi Lu Jennifer M. MacDonald Lukas J. Neukomm Amy E. Sheehan Rachel Bradshaw Mary A. Logan Marc R. Freeman
author_facet	Tsai-Yi Lu Jennifer M. MacDonald Lukas J. Neukomm Amy E. Sheehan Rachel Bradshaw Mary A. Logan Marc R. Freeman
author_sort	Tsai-Yi Lu
title	Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
title_short	Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
title_full	Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
title_fullStr	Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
title_full_unstemmed	Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
title_sort	axon degeneration induces glial responses through draper-traf4-jnk signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0803d1cf18d4b59932815bc571bcf90
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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

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