Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil

Abstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia...

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Autores principales:	João Silveira Moledo Gesto, Gabriel Sylvestre Ribeiro, Marcele Neves Rocha, Fernando Braga Stehling Dias, Julia Peixoto, Fabiano Duarte Carvalho, Thiago Nunes Pereira, Luciano Andrade Moreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a08174d192d44cd8bbb2f24167134d8b
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spelling	oai:doaj.org-article:a08174d192d44cd8bbb2f24167134d8b2021-12-02T17:01:43ZReduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil10.1038/s41598-021-89409-82045-2322https://doaj.org/article/a08174d192d44cd8bbb2f24167134d8b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89409-8https://doaj.org/toc/2045-2322Abstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia’s ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.João Silveira Moledo GestoGabriel Sylvestre RibeiroMarcele Neves RochaFernando Braga Stehling DiasJulia PeixotoFabiano Duarte CarvalhoThiago Nunes PereiraLuciano Andrade MoreiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
description	Abstract Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia’s ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.
format	article
author	João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira
author_facet	João Silveira Moledo Gesto Gabriel Sylvestre Ribeiro Marcele Neves Rocha Fernando Braga Stehling Dias Julia Peixoto Fabiano Duarte Carvalho Thiago Nunes Pereira Luciano Andrade Moreira
author_sort	João Silveira Moledo Gesto
title	Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_short	Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_full	Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_fullStr	Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_full_unstemmed	Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil
title_sort	reduced competence to arboviruses following the sustainable invasion of wolbachia into native aedes aegypti from southeastern brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a08174d192d44cd8bbb2f24167134d8b
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Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil

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