Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report

Abstract Background Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase the...

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Autores principales:	Yi Xie, Jia Wen, Zhihua Zhao, Hongbo Liu, Nanchang Xie
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Multiple auto-antibody Autoimmune encephalitis Anti-LGI1 Anti- GABABR1 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a081d87d99664f18ba600145f029760d
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spelling	oai:doaj.org-article:a081d87d99664f18ba600145f029760d2021-11-28T12:11:23ZAutoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report10.1186/s12883-021-02460-w1471-2377https://doaj.org/article/a081d87d99664f18ba600145f029760d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02460-whttps://doaj.org/toc/1471-2377Abstract Background Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase the recurrence rate and mortality. The coexistence of anti-Leucinie-rich Glioma Inactivated 1 (LGI1) and anti-γ-aminobutyric acid-beta-receptor 1 (GABABR1) has not been published before. Case presentation We herein present the case of a 60-year-old man with slow response, behavioral changes, psychosis and sleep disorders. Laboratory test included serum hyponatremia, positive serum LGI1 and GABABR1 antibodies using transfected cell-based assays. Electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid impulse treatment and sodium supplement therapy, and did not recur during the follow-up. Conclusions Here we report the first AE characterized by positive LGI1 and GABABR1 antibodies, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.Yi XieJia WenZhihua ZhaoHongbo LiuNanchang XieBMCarticleMultiple auto-antibodyAutoimmune encephalitisAnti-LGI1Anti- GABABR1Neurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple auto-antibody Autoimmune encephalitis Anti-LGI1 Anti- GABABR1 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Multiple auto-antibody Autoimmune encephalitis Anti-LGI1 Anti- GABABR1 Neurology. Diseases of the nervous system RC346-429 Yi Xie Jia Wen Zhihua Zhao Hongbo Liu Nanchang Xie Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
description	Abstract Background Autoimmune encephalitis (AE) with multiple auto-antibodies is of great clinical significance because its complex clinical manifestations and atypical imaging increase the difficulty of diagnosis, differential diagnosis and treatment, which may aggravate the disease, increase the recurrence rate and mortality. The coexistence of anti-Leucinie-rich Glioma Inactivated 1 (LGI1) and anti-γ-aminobutyric acid-beta-receptor 1 (GABABR1) has not been published before. Case presentation We herein present the case of a 60-year-old man with slow response, behavioral changes, psychosis and sleep disorders. Laboratory test included serum hyponatremia, positive serum LGI1 and GABABR1 antibodies using transfected cell-based assays. Electroencephalogram exhibited moderate diffusion abnormality. The patient responded well to steroid impulse treatment and sodium supplement therapy, and did not recur during the follow-up. Conclusions Here we report the first AE characterized by positive LGI1 and GABABR1 antibodies, as well as summarizing AE with multiple auto-antibodies reported so far, hopefully to provide experience for clinical practice.
format	article
author	Yi Xie Jia Wen Zhihua Zhao Hongbo Liu Nanchang Xie
author_facet	Yi Xie Jia Wen Zhihua Zhao Hongbo Liu Nanchang Xie
author_sort	Yi Xie
title	Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
title_short	Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
title_full	Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
title_fullStr	Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
title_full_unstemmed	Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report
title_sort	autoimmune encephalitis with coexistent lgi1 and gababr1 antibodies: case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a081d87d99664f18ba600145f029760d
work_keys_str_mv	AT yixie autoimmuneencephalitiswithcoexistentlgi1andgababr1antibodiescasereport AT jiawen autoimmuneencephalitiswithcoexistentlgi1andgababr1antibodiescasereport AT zhihuazhao autoimmuneencephalitiswithcoexistentlgi1andgababr1antibodiescasereport AT hongboliu autoimmuneencephalitiswithcoexistentlgi1andgababr1antibodiescasereport AT nanchangxie autoimmuneencephalitiswithcoexistentlgi1andgababr1antibodiescasereport
_version_	1718408157777100800

Autoimmune encephalitis with coexistent LGI1 and GABABR1 antibodies: case report

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