Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.

There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchor...

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Autores principales:	Ana Bribián, Xavier Fontana, Franc Llorens, Rosalina Gavín, Manuel Reina, José Manuel García-Verdugo, Juan María Torres, Fernando de Castro, José Antonio del Río
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0829819709e4aeea6916b16ed3d936e
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spelling	oai:doaj.org-article:a0829819709e4aeea6916b16ed3d936e2021-11-18T07:21:52ZRole of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.1932-620310.1371/journal.pone.0033872https://doaj.org/article/a0829819709e4aeea6916b16ed3d936e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22529900/?tool=EBIhttps://doaj.org/toc/1932-6203There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrP(c) influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrP(c) proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrP(c) knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells.Ana BribiánXavier FontanaFranc LlorensRosalina GavínManuel ReinaJosé Manuel García-VerdugoJuan María TorresFernando de CastroJosé Antonio del RíoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e33872 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Bribián Xavier Fontana Franc Llorens Rosalina Gavín Manuel Reina José Manuel García-Verdugo Juan María Torres Fernando de Castro José Antonio del Río Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
description	There are numerous studies describing the signaling mechanisms that mediate oligodendrocyte precursor cell (OPC) proliferation and differentiation, although the contribution of the cellular prion protein (PrP(c)) to this process remains unclear. PrP(c) is a glycosyl-phosphatidylinositol (GPI)-anchored glycoprotein involved in diverse cellular processes during the development and maturation of the mammalian central nervous system (CNS). Here we describe how PrP(c) influences oligodendrocyte proliferation in the developing and adult CNS. OPCs that lack PrP(c) proliferate more vigorously at the expense of a delay in differentiation, which correlates with changes in the expression of oligodendrocyte lineage markers. In addition, numerous NG2-positive cells were observed in cortical regions of adult PrP(c) knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells.
format	article
author	Ana Bribián Xavier Fontana Franc Llorens Rosalina Gavín Manuel Reina José Manuel García-Verdugo Juan María Torres Fernando de Castro José Antonio del Río
author_facet	Ana Bribián Xavier Fontana Franc Llorens Rosalina Gavín Manuel Reina José Manuel García-Verdugo Juan María Torres Fernando de Castro José Antonio del Río
author_sort	Ana Bribián
title	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
title_short	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
title_full	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
title_fullStr	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
title_full_unstemmed	Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.
title_sort	role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse cns.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a0829819709e4aeea6916b16ed3d936e
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Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS.

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