Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.

Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket.

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates it...

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Autores principales: Pruthvi Raj Bejugam, Raja R Kuppili, Nitu Singh, Nikhil Gadewal, Lalith K Chaganti, G Madhavi Sastry, Kakoli Bose
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/a082cf1738d54a3ebf60f793d87e6eb6
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