Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B

Abstract Repurposing existing compounds for new indications may facilitate the discovery of skin prebiotics which have not been well defined. Four compounds that have been registered by the International Nomenclature of Cosmetic Ingredients (INCI) were included to study their abilities to induce the...

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Autores principales:	Arun Balasubramaniam, Prakoso Adi, Do Thi Tra My, Sunita Keshari, Raman Sankar, Chien-Lung Chen, Chun-Ming Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a083f98b2801403896706e8996f0ceba
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spelling	oai:doaj.org-article:a083f98b2801403896706e8996f0ceba2021-12-02T11:43:50ZRepurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B10.1038/s41598-020-78132-52045-2322https://doaj.org/article/a083f98b2801403896706e8996f0ceba2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78132-5https://doaj.org/toc/2045-2322Abstract Repurposing existing compounds for new indications may facilitate the discovery of skin prebiotics which have not been well defined. Four compounds that have been registered by the International Nomenclature of Cosmetic Ingredients (INCI) were included to study their abilities to induce the fermentation of Staphylococcus epidermidis (S. epidermidis), a bacterial species abundant in the human skin. Liquid coco-caprylate/caprate (LCC), originally used as an emollient, effectively initiated the fermentation of S. epidermidis ATCC 12228, produced short-chain fatty acids (SCFAs), and provoked robust electricity. Application of LCC plus electrogenic S. epidermidis ATCC 12228 on mouse skin significantly reduced ultraviolet B (UV-B)-induced injuries which were evaluated by the formation of 4-hydroxynonenal (4-HNE), cyclobutane pyrimidine dimers (CPD), and skin lesions. A S. epidermidis S2 isolate with low expressions of genes encoding pyruvate dehydrogenase (pdh), and phosphate acetyltransferase (pta) was found to be poorly electrogenic. The protective action of electrogenic S. epidermidis against UV-B-induced skin injuries was considerably suppressed when mouse skin was applied with LCC in combination with a poorly electrogenic S. epidermidis S2 isolate. Exploring new indication of LCC for promoting S. epidermidis against UV-B provided an example of repurposing INCI-registered compounds as skin prebiotics.Arun BalasubramaniamPrakoso AdiDo Thi Tra MySunita KeshariRaman SankarChien-Lung ChenChun-Ming HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arun Balasubramaniam Prakoso Adi Do Thi Tra My Sunita Keshari Raman Sankar Chien-Lung Chen Chun-Ming Huang Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
description	Abstract Repurposing existing compounds for new indications may facilitate the discovery of skin prebiotics which have not been well defined. Four compounds that have been registered by the International Nomenclature of Cosmetic Ingredients (INCI) were included to study their abilities to induce the fermentation of Staphylococcus epidermidis (S. epidermidis), a bacterial species abundant in the human skin. Liquid coco-caprylate/caprate (LCC), originally used as an emollient, effectively initiated the fermentation of S. epidermidis ATCC 12228, produced short-chain fatty acids (SCFAs), and provoked robust electricity. Application of LCC plus electrogenic S. epidermidis ATCC 12228 on mouse skin significantly reduced ultraviolet B (UV-B)-induced injuries which were evaluated by the formation of 4-hydroxynonenal (4-HNE), cyclobutane pyrimidine dimers (CPD), and skin lesions. A S. epidermidis S2 isolate with low expressions of genes encoding pyruvate dehydrogenase (pdh), and phosphate acetyltransferase (pta) was found to be poorly electrogenic. The protective action of electrogenic S. epidermidis against UV-B-induced skin injuries was considerably suppressed when mouse skin was applied with LCC in combination with a poorly electrogenic S. epidermidis S2 isolate. Exploring new indication of LCC for promoting S. epidermidis against UV-B provided an example of repurposing INCI-registered compounds as skin prebiotics.
format	article
author	Arun Balasubramaniam Prakoso Adi Do Thi Tra My Sunita Keshari Raman Sankar Chien-Lung Chen Chun-Ming Huang
author_facet	Arun Balasubramaniam Prakoso Adi Do Thi Tra My Sunita Keshari Raman Sankar Chien-Lung Chen Chun-Ming Huang
author_sort	Arun Balasubramaniam
title	Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
title_short	Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
title_full	Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
title_fullStr	Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
title_full_unstemmed	Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B
title_sort	repurposing inci-registered compounds as skin prebiotics for probiotic staphylococcus epidermidis against uv-b
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a083f98b2801403896706e8996f0ceba
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Repurposing INCI-registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV-B

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