Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are associated with cell count and disease susceptibility.
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Nature Portfolio
2021
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oai:doaj.org-article:a08e861a297c4eba8c835747ae9b90f82021-12-02T14:25:16ZGenetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease10.1038/s41467-021-22548-82041-1723https://doaj.org/article/a08e861a297c4eba8c835747ae9b90f82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22548-8https://doaj.org/toc/2041-1723PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are associated with cell count and disease susceptibility.Stephen WattLouella VasquezKlaudia WalterAlice L. MannKousik KunduLu ChenYing SimsSimone EckerFrances BurdenSamantha FarrowBen FarrValentina IotchkovaHeather EldingDaniel MeadManuel TardaguilaHannes PonstinglDavid RichardsonAvik DattaPaul FlicekLaura ClarkeKate DownesTomi PastinenPeter FraserMattia FrontiniBiola-Maria JavierreMikhail SpivakovNicole SoranzoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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DOAJ |
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Science Q |
| spellingShingle |
Science Q Stephen Watt Louella Vasquez Klaudia Walter Alice L. Mann Kousik Kundu Lu Chen Ying Sims Simone Ecker Frances Burden Samantha Farrow Ben Farr Valentina Iotchkova Heather Elding Daniel Mead Manuel Tardaguila Hannes Ponstingl David Richardson Avik Datta Paul Flicek Laura Clarke Kate Downes Tomi Pastinen Peter Fraser Mattia Frontini Biola-Maria Javierre Mikhail Spivakov Nicole Soranzo Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| description |
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are associated with cell count and disease susceptibility. |
| format |
article |
| author |
Stephen Watt Louella Vasquez Klaudia Walter Alice L. Mann Kousik Kundu Lu Chen Ying Sims Simone Ecker Frances Burden Samantha Farrow Ben Farr Valentina Iotchkova Heather Elding Daniel Mead Manuel Tardaguila Hannes Ponstingl David Richardson Avik Datta Paul Flicek Laura Clarke Kate Downes Tomi Pastinen Peter Fraser Mattia Frontini Biola-Maria Javierre Mikhail Spivakov Nicole Soranzo |
| author_facet |
Stephen Watt Louella Vasquez Klaudia Walter Alice L. Mann Kousik Kundu Lu Chen Ying Sims Simone Ecker Frances Burden Samantha Farrow Ben Farr Valentina Iotchkova Heather Elding Daniel Mead Manuel Tardaguila Hannes Ponstingl David Richardson Avik Datta Paul Flicek Laura Clarke Kate Downes Tomi Pastinen Peter Fraser Mattia Frontini Biola-Maria Javierre Mikhail Spivakov Nicole Soranzo |
| author_sort |
Stephen Watt |
| title |
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| title_short |
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| title_full |
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| title_fullStr |
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| title_full_unstemmed |
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| title_sort |
genetic perturbation of pu.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a08e861a297c4eba8c835747ae9b90f8 |
| work_keys_str_mv |
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