The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone

Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillati...

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Autores principales:	Yurika Numata-Uematsu, Mitsugu Uematsu, Rie Sakuraba, Masaki Iwasaki, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Shigeo Kure
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	surgery epileptogenic zone epilepsy interictal onset spike-related ripples Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a08f7d6f0da8419d8ffbacc4883d36e1
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spelling	oai:doaj.org-article:a08f7d6f0da8419d8ffbacc4883d36e12021-11-04T05:34:39ZThe Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone1664-229510.3389/fneur.2021.724417https://doaj.org/article/a08f7d6f0da8419d8ffbacc4883d36e12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.724417/fullhttps://doaj.org/toc/1664-2295Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ.Methods: The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80–200 Hz) and investigated whether they are within the resection area.Results: We retrospectively examined 12 serial patients who achieved seizure-free status after focal resection surgery. Using the method that we developed, we determined the onset channels of interictal spike-related ripples and found that for all 12 patients, they were among the resection channels. The onset frequencies of ripples were in the range of 80–150 Hz. However, the ictal onset channels (evaluated based on ictal ECoG patterns) and ripple onset channels coincided in only 3 of 12 patients.Conclusions: Determining the onset area of interictal spike-related ripples could facilitate EZ estimation. This simple method that utilizes interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.Yurika Numata-UematsuMitsugu UematsuRie SakurabaMasaki IwasakiMasaki IwasakiShinichiro OsawaKazutaka JinNobukazu NakasatoShigeo KureFrontiers Media S.A.articlesurgeryepileptogenic zoneepilepsyinterictalonsetspike-related ripplesNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	surgery epileptogenic zone epilepsy interictal onset spike-related ripples Neurology. Diseases of the nervous system RC346-429
spellingShingle	surgery epileptogenic zone epilepsy interictal onset spike-related ripples Neurology. Diseases of the nervous system RC346-429 Yurika Numata-Uematsu Mitsugu Uematsu Rie Sakuraba Masaki Iwasaki Masaki Iwasaki Shinichiro Osawa Kazutaka Jin Nobukazu Nakasato Shigeo Kure The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
description	Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ.Methods: The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80–200 Hz) and investigated whether they are within the resection area.Results: We retrospectively examined 12 serial patients who achieved seizure-free status after focal resection surgery. Using the method that we developed, we determined the onset channels of interictal spike-related ripples and found that for all 12 patients, they were among the resection channels. The onset frequencies of ripples were in the range of 80–150 Hz. However, the ictal onset channels (evaluated based on ictal ECoG patterns) and ripple onset channels coincided in only 3 of 12 patients.Conclusions: Determining the onset area of interictal spike-related ripples could facilitate EZ estimation. This simple method that utilizes interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.
format	article
author	Yurika Numata-Uematsu Mitsugu Uematsu Rie Sakuraba Masaki Iwasaki Masaki Iwasaki Shinichiro Osawa Kazutaka Jin Nobukazu Nakasato Shigeo Kure
author_facet	Yurika Numata-Uematsu Mitsugu Uematsu Rie Sakuraba Masaki Iwasaki Masaki Iwasaki Shinichiro Osawa Kazutaka Jin Nobukazu Nakasato Shigeo Kure
author_sort	Yurika Numata-Uematsu
title	The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
title_short	The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
title_full	The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
title_fullStr	The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
title_full_unstemmed	The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone
title_sort	onset of interictal spike-related ripples facilitates detection of the epileptogenic zone
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a08f7d6f0da8419d8ffbacc4883d36e1
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The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone

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