Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection

Abstract To investigate that the bacteriological concentration and pH value in peritoneal drainage fluid might serve as indicators of early diagnosis of anastomotic leakage following rectal resection. We prospectively analyzed consecutive patients who were treated for rectal diseases with anastomosi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei Ge, Hai-yan Gong, Yong-quan Xia, Li-hua Shao, Han Shen, Gang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a08fee2017a94677b8ef34cab32aa41b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a08fee2017a94677b8ef34cab32aa41b
record_format	dspace
spelling	oai:doaj.org-article:a08fee2017a94677b8ef34cab32aa41b2021-12-05T12:16:15ZBacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection10.1038/s41598-021-02649-62045-2322https://doaj.org/article/a08fee2017a94677b8ef34cab32aa41b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02649-6https://doaj.org/toc/2045-2322Abstract To investigate that the bacteriological concentration and pH value in peritoneal drainage fluid might serve as indicators of early diagnosis of anastomotic leakage following rectal resection. We prospectively analyzed consecutive patients who were treated for rectal diseases with anastomosis at the department of general surgery, the affiliated hospital of Nanjing University Medical School between August 2018 and December 2020. The bacteriological concentration and the pH value in peritoneal drainage fluid were tested on the first, fourth, seventh days postoperatively. A total of 300 consecutive patients underwent rectal resection were tested. 21 patients present with AL and the overall AL rate was 7%. The bacteriological concentration in peritoneal drainage fluid of AL group was significantly higher than that in non-AL group. The AUC value was 0.98 (95% confidence intervals 0.969–1.000) according to the ROC curve. The best cut-off value was 1143/uL. The sensitivity and specificity were 100% and 93.19% respectively. There was no difference of pH value between the AL and non-AL groups. According the results of present study, a high bacteriological concentration in peritoneal drainage fluid is a good marker for predicting and diagnosing AL following rectal resection. However, owing to the limitation of the sample, there was no validation attempt in the study. A large sample study is needed to validate the conclusion.Wei GeHai-yan GongYong-quan XiaLi-hua ShaoHan ShenGang ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Ge Hai-yan Gong Yong-quan Xia Li-hua Shao Han Shen Gang Chen Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
description	Abstract To investigate that the bacteriological concentration and pH value in peritoneal drainage fluid might serve as indicators of early diagnosis of anastomotic leakage following rectal resection. We prospectively analyzed consecutive patients who were treated for rectal diseases with anastomosis at the department of general surgery, the affiliated hospital of Nanjing University Medical School between August 2018 and December 2020. The bacteriological concentration and the pH value in peritoneal drainage fluid were tested on the first, fourth, seventh days postoperatively. A total of 300 consecutive patients underwent rectal resection were tested. 21 patients present with AL and the overall AL rate was 7%. The bacteriological concentration in peritoneal drainage fluid of AL group was significantly higher than that in non-AL group. The AUC value was 0.98 (95% confidence intervals 0.969–1.000) according to the ROC curve. The best cut-off value was 1143/uL. The sensitivity and specificity were 100% and 93.19% respectively. There was no difference of pH value between the AL and non-AL groups. According the results of present study, a high bacteriological concentration in peritoneal drainage fluid is a good marker for predicting and diagnosing AL following rectal resection. However, owing to the limitation of the sample, there was no validation attempt in the study. A large sample study is needed to validate the conclusion.
format	article
author	Wei Ge Hai-yan Gong Yong-quan Xia Li-hua Shao Han Shen Gang Chen
author_facet	Wei Ge Hai-yan Gong Yong-quan Xia Li-hua Shao Han Shen Gang Chen
author_sort	Wei Ge
title	Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
title_short	Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
title_full	Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
title_fullStr	Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
title_full_unstemmed	Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
title_sort	bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a08fee2017a94677b8ef34cab32aa41b
work_keys_str_mv	AT weige bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection AT haiyangong bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection AT yongquanxia bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection AT lihuashao bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection AT hanshen bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection AT gangchen bacteriologicalconcentrationofperitonealdrainagefluidcouldmakeanearlydiagnosisofanastomoticleakagefollowingrectalresection
_version_	1718372091152039936

Bacteriological concentration of peritoneal drainage fluid could make an early diagnosis of anastomotic leakage following rectal resection

Ejemplares similares