Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test

Background: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to a...

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Autores principales:	Rodrigo Fernández-Verdejo, Lorena Malo-Vintimilla, Juan Gutiérrez-Pino, Antonio López-Fuenzalida, Pablo Olmos, Pablo Irarrazaval, Jose E. Galgani
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carbohydrate metabolism insulin sensitivity insulin resistance lipid metabolism fuel selection Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/a0908a5c838c4aa5b71630057241c025
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spelling	oai:doaj.org-article:a0908a5c838c4aa5b71630057241c0252021-11-16T07:48:25ZSimilar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test2296-861X10.3389/fnut.2021.745907https://doaj.org/article/a0908a5c838c4aa5b71630057241c0252021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.745907/fullhttps://doaj.org/toc/2296-861XBackground: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT).Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; High-MetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups.Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index.Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat.Rodrigo Fernández-VerdejoRodrigo Fernández-VerdejoLorena Malo-VintimillaJuan Gutiérrez-PinoAntonio López-FuenzalidaAntonio López-FuenzalidaPablo OlmosPablo IrarrazavalJose E. GalganiJose E. GalganiFrontiers Media S.A.articlecarbohydrate metabolisminsulin sensitivityinsulin resistancelipid metabolismfuel selectionNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbohydrate metabolism insulin sensitivity insulin resistance lipid metabolism fuel selection Nutrition. Foods and food supply TX341-641
spellingShingle	carbohydrate metabolism insulin sensitivity insulin resistance lipid metabolism fuel selection Nutrition. Foods and food supply TX341-641 Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo Lorena Malo-Vintimilla Juan Gutiérrez-Pino Antonio López-Fuenzalida Antonio López-Fuenzalida Pablo Olmos Pablo Irarrazaval Jose E. Galgani Jose E. Galgani Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
description	Background: Low metabolic flexibility (MetF) may be an underlying factor for metabolic health impairment. Individuals with low MetF are thus expected to have worse metabolic health than subjects with high MetF. Therefore, we aimed to compare metabolic health in individuals with contrasting MetF to an oral glucose tolerance test (OGTT).Methods: In individuals with excess body weight, we measured MetF as the change in respiratory quotient (RQ) from fasting to 1 h after ingestion of a 75-g glucose load (i.e., OGTT). Individuals were then grouped into low and high MetF (Low-MetF n = 12; High-MetF n = 13). The groups had similar body mass index, body fat, sex, age, and maximum oxygen uptake. Metabolic health markers (clinical markers, insulin sensitivity/resistance, abdominal fat, and intrahepatic fat) were compared between groups.Results: Fasting glucose, triglycerides (TG), and high-density lipoprotein (HDL) were similar between groups. So were insulin sensitivity/resistance, visceral, and intrahepatic fat. Nevertheless, High-MetF individuals had higher diastolic blood pressure, a larger drop in TG concentration during the OGTT, and a borderline significant (P = 0.05) higher Subcutaneous Adipose Tissue (SAT). Further, compared to Low-MetF, High-MetF individuals had an about 2-fold steeper slope for the relationship between SAT and fat mass index.Conclusion: Individuals with contrasting MetF to an OGTT had similar metabolic health. Yet High-MetF appears related to enhanced circulating TG clearance and enlarged subcutaneous fat.
format	article
author	Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo Lorena Malo-Vintimilla Juan Gutiérrez-Pino Antonio López-Fuenzalida Antonio López-Fuenzalida Pablo Olmos Pablo Irarrazaval Jose E. Galgani Jose E. Galgani
author_facet	Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo Lorena Malo-Vintimilla Juan Gutiérrez-Pino Antonio López-Fuenzalida Antonio López-Fuenzalida Pablo Olmos Pablo Irarrazaval Jose E. Galgani Jose E. Galgani
author_sort	Rodrigo Fernández-Verdejo
title	Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
title_short	Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
title_full	Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
title_fullStr	Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
title_full_unstemmed	Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test
title_sort	similar metabolic health in overweight/obese individuals with contrasting metabolic flexibility to an oral glucose tolerance test
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a0908a5c838c4aa5b71630057241c025
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Similar Metabolic Health in Overweight/Obese Individuals With Contrasting Metabolic Flexibility to an Oral Glucose Tolerance Test

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