Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients

Abstract Introduction Because of limited information of Sertoli–Leydig cell tumors (SLCTs), the objective aimed to describe clinical parameters, management and treatment results of SLCTs. Material and methods We retrospectively reviewed 15 cases with SLCTs, who were treated in the Affiliated Hospita...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guangning Wang, Ran Zhang, Chuan Li, Aiping Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sertoli–Leydig cell tumors SLCTs Conservative surgery Chemotherapy Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/a09404ccb7b349ab900dd3d24757549a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a09404ccb7b349ab900dd3d24757549a
record_format	dspace
spelling	oai:doaj.org-article:a09404ccb7b349ab900dd3d24757549a2021-11-08T11:03:53ZCharacteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients10.1186/s13048-021-00909-71757-2215https://doaj.org/article/a09404ccb7b349ab900dd3d24757549a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13048-021-00909-7https://doaj.org/toc/1757-2215Abstract Introduction Because of limited information of Sertoli–Leydig cell tumors (SLCTs), the objective aimed to describe clinical parameters, management and treatment results of SLCTs. Material and methods We retrospectively reviewed 15 cases with SLCTs, who were treated in the Affiliated Hospital of Qingdao University between 2009 and 2020. Data of clinical parameters and treatment was studied. Results The age ranged 25–69 years. Elevated testosterone was observed in 4 patients. FIGO-stage: 14 were at Ia(10 moderately differentiated, 3 poorly differentiated, 5 retiform pattern).1 was at Ic. Patients with retiform pattern were more likely to exhibit endocrine function (p = 0.019, w = 0.61) and tumor diameter was significantly bigger in no endocrine function (p = 0.012, d = 1.52). All patients received surgical treatment. 8 received postoperative chemotherapy. The median follow-up was 66 months (20–112 months). 1 patient relapsed within 36 months and received cytoreductive surgery. She survived without disease after recurrence treatment. Of 5 patients who performed fertility sparing surgeries with the desire of childbirth, 3 had full-term pregnancy and 1 experienced a miscarriage. Another one has not tried to conceive. Conclusion The prognosis of SLCTs is good. Our data showed patients with retiform pattern were more likely to exhibit endocrine function. The diameter of tumor was significantly bigger in no endocrine function. Conservative surgery is the preferred option for patients with the desire of fertility at stage Ia. Postoperative chemotherapy is advised to cases with high-risk factors, but the most effective chemotherapy regimen is still uncertain.Guangning WangRan ZhangChuan LiAiping ChenBMCarticleSertoli–Leydig cell tumorsSLCTsConservative surgeryChemotherapyGynecology and obstetricsRG1-991ENJournal of Ovarian Research, Vol 14, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sertoli–Leydig cell tumors SLCTs Conservative surgery Chemotherapy Gynecology and obstetrics RG1-991
spellingShingle	Sertoli–Leydig cell tumors SLCTs Conservative surgery Chemotherapy Gynecology and obstetrics RG1-991 Guangning Wang Ran Zhang Chuan Li Aiping Chen Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
description	Abstract Introduction Because of limited information of Sertoli–Leydig cell tumors (SLCTs), the objective aimed to describe clinical parameters, management and treatment results of SLCTs. Material and methods We retrospectively reviewed 15 cases with SLCTs, who were treated in the Affiliated Hospital of Qingdao University between 2009 and 2020. Data of clinical parameters and treatment was studied. Results The age ranged 25–69 years. Elevated testosterone was observed in 4 patients. FIGO-stage: 14 were at Ia(10 moderately differentiated, 3 poorly differentiated, 5 retiform pattern).1 was at Ic. Patients with retiform pattern were more likely to exhibit endocrine function (p = 0.019, w = 0.61) and tumor diameter was significantly bigger in no endocrine function (p = 0.012, d = 1.52). All patients received surgical treatment. 8 received postoperative chemotherapy. The median follow-up was 66 months (20–112 months). 1 patient relapsed within 36 months and received cytoreductive surgery. She survived without disease after recurrence treatment. Of 5 patients who performed fertility sparing surgeries with the desire of childbirth, 3 had full-term pregnancy and 1 experienced a miscarriage. Another one has not tried to conceive. Conclusion The prognosis of SLCTs is good. Our data showed patients with retiform pattern were more likely to exhibit endocrine function. The diameter of tumor was significantly bigger in no endocrine function. Conservative surgery is the preferred option for patients with the desire of fertility at stage Ia. Postoperative chemotherapy is advised to cases with high-risk factors, but the most effective chemotherapy regimen is still uncertain.
format	article
author	Guangning Wang Ran Zhang Chuan Li Aiping Chen
author_facet	Guangning Wang Ran Zhang Chuan Li Aiping Chen
author_sort	Guangning Wang
title	Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
title_short	Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
title_full	Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
title_fullStr	Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
title_full_unstemmed	Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients
title_sort	characteristics and outcomes analysis of ovarian sertoli–leydig cell tumors (slcts): analysis of 15 patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a09404ccb7b349ab900dd3d24757549a
work_keys_str_mv	AT guangningwang characteristicsandoutcomesanalysisofovariansertolileydigcelltumorsslctsanalysisof15patients AT ranzhang characteristicsandoutcomesanalysisofovariansertolileydigcelltumorsslctsanalysisof15patients AT chuanli characteristicsandoutcomesanalysisofovariansertolileydigcelltumorsslctsanalysisof15patients AT aipingchen characteristicsandoutcomesanalysisofovariansertolileydigcelltumorsslctsanalysisof15patients
_version_	1718442453022801920

Characteristics and outcomes analysis of ovarian Sertoli–Leydig cell tumors (SLCTs): analysis of 15 patients

Ejemplares similares