Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

Viral analogs of B-cell lymphoma 2 (Bcl2), known as vBcl2s, control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, García-Murria et al. report on transmembrane domains (TMDs) in the C-terminal hydrophobic region of herpes- and poxviral vBcl2s, which medi...

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Autores principales:	Maria Jesús García-Murria, Gerard Duart, Brayan Grau, Elisabet Diaz-Beneitez, Dolores Rodríguez, Ismael Mingarro, Luis Martínez-Gil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a095ff7f2cb74e3786be3ecd772374a0
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spelling	oai:doaj.org-article:a095ff7f2cb74e3786be3ecd772374a02021-12-02T15:33:52ZViral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis10.1038/s41467-020-19881-92041-1723https://doaj.org/article/a095ff7f2cb74e3786be3ecd772374a02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19881-9https://doaj.org/toc/2041-1723Viral analogs of B-cell lymphoma 2 (Bcl2), known as vBcl2s, control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, García-Murria et al. report on transmembrane domains (TMDs) in the C-terminal hydrophobic region of herpes- and poxviral vBcl2s, which mediate homo-oligomerization and interactions with cellular Bcl2 TMDs to control apoptosis.Maria Jesús García-MurriaGerard DuartBrayan GrauElisabet Diaz-BeneitezDolores RodríguezIsmael MingarroLuis Martínez-GilNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Jesús García-Murria Gerard Duart Brayan Grau Elisabet Diaz-Beneitez Dolores Rodríguez Ismael Mingarro Luis Martínez-Gil Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
description	Viral analogs of B-cell lymphoma 2 (Bcl2), known as vBcl2s, control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, García-Murria et al. report on transmembrane domains (TMDs) in the C-terminal hydrophobic region of herpes- and poxviral vBcl2s, which mediate homo-oligomerization and interactions with cellular Bcl2 TMDs to control apoptosis.
format	article
author	Maria Jesús García-Murria Gerard Duart Brayan Grau Elisabet Diaz-Beneitez Dolores Rodríguez Ismael Mingarro Luis Martínez-Gil
author_facet	Maria Jesús García-Murria Gerard Duart Brayan Grau Elisabet Diaz-Beneitez Dolores Rodríguez Ismael Mingarro Luis Martínez-Gil
author_sort	Maria Jesús García-Murria
title	Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
title_short	Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
title_full	Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
title_fullStr	Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
title_full_unstemmed	Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
title_sort	viral bcl2s’ transmembrane domain interact with host bcl2 proteins to control cellular apoptosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a095ff7f2cb74e3786be3ecd772374a0
work_keys_str_mv	AT mariajesusgarciamurria viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT gerardduart viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT brayangrau viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT elisabetdiazbeneitez viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT doloresrodriguez viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT ismaelmingarro viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis AT luismartinezgil viralbcl2stransmembranedomaininteractwithhostbcl2proteinstocontrolcellularapoptosis
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Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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