Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.

Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation.

<h4>Background</h4>Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized that circulating cell-free mtDNA levels would be assoc...

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Main Authors: Kiichi Nakahira, Sun-Young Kyung, Angela J Rogers, Lee Gazourian, Sojung Youn, Anthony F Massaro, Carolina Quintana, Juan C Osorio, Zhaoxi Wang, Yang Zhao, Laurie A Lawler, Jason D Christie, Nuala J Meyer, Finnian R Mc Causland, Sushrut S Waikar, Aaron B Waxman, Raymond T Chung, Raphael Bueno, Ivan O Rosas, Laura E Fredenburgh, Rebecca M Baron, David C Christiani, Gary M Hunninghake, Augustine M K Choi
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Online Access:https://doaj.org/article/a097565b6e554756bb16df4e4573238a
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https://doaj.org/article/a097565b6e554756bb16df4e4573238a

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