Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge

The Mre11/Rad50 complex, which functions in genome surveillance, possesses antiparallel coiled-coil arms forming a ring-like structure similar to that of the SMC family proteins. Here the authors find that the Rad50 zinc hook functions similarly to the hinge of the SMC protein, and that the ring str...

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Autores principales:	Hisashi Tatebe, Chew Theng Lim, Hiroki Konno, Kazuhiro Shiozaki, Akira Shinohara, Takayuki Uchihashi, Asako Furukohri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0985c5563bd43b498daec3196d6c305
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spelling	oai:doaj.org-article:a0985c5563bd43b498daec3196d6c3052021-12-02T15:39:29ZRad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge10.1038/s41467-019-14025-02041-1723https://doaj.org/article/a0985c5563bd43b498daec3196d6c3052020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14025-0https://doaj.org/toc/2041-1723The Mre11/Rad50 complex, which functions in genome surveillance, possesses antiparallel coiled-coil arms forming a ring-like structure similar to that of the SMC family proteins. Here the authors find that the Rad50 zinc hook functions similarly to the hinge of the SMC protein, and that the ring structure of the Mre11/Rad50 dimer also opens by disconnecting its globular head domains.Hisashi TatebeChew Theng LimHiroki KonnoKazuhiro ShiozakiAkira ShinoharaTakayuki UchihashiAsako FurukohriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hisashi Tatebe Chew Theng Lim Hiroki Konno Kazuhiro Shiozaki Akira Shinohara Takayuki Uchihashi Asako Furukohri Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
description	The Mre11/Rad50 complex, which functions in genome surveillance, possesses antiparallel coiled-coil arms forming a ring-like structure similar to that of the SMC family proteins. Here the authors find that the Rad50 zinc hook functions similarly to the hinge of the SMC protein, and that the ring structure of the Mre11/Rad50 dimer also opens by disconnecting its globular head domains.
format	article
author	Hisashi Tatebe Chew Theng Lim Hiroki Konno Kazuhiro Shiozaki Akira Shinohara Takayuki Uchihashi Asako Furukohri
author_facet	Hisashi Tatebe Chew Theng Lim Hiroki Konno Kazuhiro Shiozaki Akira Shinohara Takayuki Uchihashi Asako Furukohri
author_sort	Hisashi Tatebe
title	Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
title_short	Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
title_full	Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
title_fullStr	Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
title_full_unstemmed	Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge
title_sort	rad50 zinc hook functions as a constitutive dimerization module interchangeable with smc hinge
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a0985c5563bd43b498daec3196d6c305
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Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge

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