Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are assoc...

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Autores principales:	Syed H. Zaidi, Tabitha A. Harrison, Amanda I. Phipps, Robert Steinfelder, Quang M. Trinh, Conghui Qu, Barbara L. Banbury, Peter Georgeson, Catherine S. Grasso, Marios Giannakis, Jeremy B. Adams, Elizabeth Alwers, Efrat L. Amitay, Richard T. Barfield, Sonja I. Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D. Buchanan, Yin Cao, Andrew T. Chan, Jenny Chang-Claude, Charles M. Connolly, David A. Drew, Alton Brad Farris, Jane C. Figueiredo, Amy J. French, Charles S. Fuchs, Levi A. Garraway, Steve Gruber, Mark A. Guinter, Stanley R. Hamilton, Sophia Harlid, Lawrence E. Heisler, Akihisa Hidaka, John L. Hopper, Wen-Yi Huang, Jeroen R. Huyghe, Mark A. Jenkins, Paul M. Krzyzanowski, Mathieu Lemire, Yi Lin, Xuemei Luo, Elaine R. Mardis, John D. McPherson, Jessica K. Miller, Victor Moreno, Xinmeng Jasmine Mu, Reiko Nishihara, Nickolas Papadopoulos, Danielle Pasternack, Michael J. Quist, Adilya Rafikova, Emma E. G. Reid, Eve Shinbrot, Brian H. Shirts, Lincoln D. Stein, Cherie D. Teney, Lee Timms, Caroline Y. Um, Bethany Van Guelpen, Megan Van Tassel, Xiaolong Wang, David A. Wheeler, Christina K. Yung, Li Hsu, Shuji Ogino, Andrea Gsur, Polly A. Newcomb, Steven Gallinger, Michael Hoffmeister, Peter T. Campbell, Stephen N. Thibodeau, Wei Sun, Thomas J. Hudson, Ulrike Peters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a09dab8e99d844a6a6258b23214b612c
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spelling	oai:doaj.org-article:a09dab8e99d844a6a6258b23214b612c2021-12-02T16:18:02ZLandscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival10.1038/s41467-020-17386-z2041-1723https://doaj.org/article/a09dab8e99d844a6a6258b23214b612c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17386-zhttps://doaj.org/toc/2041-1723Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.Syed H. ZaidiTabitha A. HarrisonAmanda I. PhippsRobert SteinfelderQuang M. TrinhConghui QuBarbara L. BanburyPeter GeorgesonCatherine S. GrassoMarios GiannakisJeremy B. AdamsElizabeth AlwersEfrat L. AmitayRichard T. BarfieldSonja I. BerndtIvan BorozanHermann BrennerStefanie BrezinaDaniel D. BuchananYin CaoAndrew T. ChanJenny Chang-ClaudeCharles M. ConnollyDavid A. DrewAlton Brad FarrisJane C. FigueiredoAmy J. FrenchCharles S. FuchsLevi A. GarrawaySteve GruberMark A. GuinterStanley R. HamiltonSophia HarlidLawrence E. HeislerAkihisa HidakaJohn L. HopperWen-Yi HuangJeroen R. HuygheMark A. JenkinsPaul M. KrzyzanowskiMathieu LemireYi LinXuemei LuoElaine R. MardisJohn D. McPhersonJessica K. MillerVictor MorenoXinmeng Jasmine MuReiko NishiharaNickolas PapadopoulosDanielle PasternackMichael J. QuistAdilya RafikovaEmma E. G. ReidEve ShinbrotBrian H. ShirtsLincoln D. SteinCherie D. TeneyLee TimmsCaroline Y. UmBethany Van GuelpenMegan Van TasselXiaolong WangDavid A. WheelerChristina K. YungLi HsuShuji OginoAndrea GsurPolly A. NewcombSteven GallingerMichael HoffmeisterPeter T. CampbellStephen N. ThibodeauWei SunThomas J. HudsonUlrike PetersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Syed H. Zaidi Tabitha A. Harrison Amanda I. Phipps Robert Steinfelder Quang M. Trinh Conghui Qu Barbara L. Banbury Peter Georgeson Catherine S. Grasso Marios Giannakis Jeremy B. Adams Elizabeth Alwers Efrat L. Amitay Richard T. Barfield Sonja I. Berndt Ivan Borozan Hermann Brenner Stefanie Brezina Daniel D. Buchanan Yin Cao Andrew T. Chan Jenny Chang-Claude Charles M. Connolly David A. Drew Alton Brad Farris Jane C. Figueiredo Amy J. French Charles S. Fuchs Levi A. Garraway Steve Gruber Mark A. Guinter Stanley R. Hamilton Sophia Harlid Lawrence E. Heisler Akihisa Hidaka John L. Hopper Wen-Yi Huang Jeroen R. Huyghe Mark A. Jenkins Paul M. Krzyzanowski Mathieu Lemire Yi Lin Xuemei Luo Elaine R. Mardis John D. McPherson Jessica K. Miller Victor Moreno Xinmeng Jasmine Mu Reiko Nishihara Nickolas Papadopoulos Danielle Pasternack Michael J. Quist Adilya Rafikova Emma E. G. Reid Eve Shinbrot Brian H. Shirts Lincoln D. Stein Cherie D. Teney Lee Timms Caroline Y. Um Bethany Van Guelpen Megan Van Tassel Xiaolong Wang David A. Wheeler Christina K. Yung Li Hsu Shuji Ogino Andrea Gsur Polly A. Newcomb Steven Gallinger Michael Hoffmeister Peter T. Campbell Stephen N. Thibodeau Wei Sun Thomas J. Hudson Ulrike Peters Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
description	Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.
format	article
author	Syed H. Zaidi Tabitha A. Harrison Amanda I. Phipps Robert Steinfelder Quang M. Trinh Conghui Qu Barbara L. Banbury Peter Georgeson Catherine S. Grasso Marios Giannakis Jeremy B. Adams Elizabeth Alwers Efrat L. Amitay Richard T. Barfield Sonja I. Berndt Ivan Borozan Hermann Brenner Stefanie Brezina Daniel D. Buchanan Yin Cao Andrew T. Chan Jenny Chang-Claude Charles M. Connolly David A. Drew Alton Brad Farris Jane C. Figueiredo Amy J. French Charles S. Fuchs Levi A. Garraway Steve Gruber Mark A. Guinter Stanley R. Hamilton Sophia Harlid Lawrence E. Heisler Akihisa Hidaka John L. Hopper Wen-Yi Huang Jeroen R. Huyghe Mark A. Jenkins Paul M. Krzyzanowski Mathieu Lemire Yi Lin Xuemei Luo Elaine R. Mardis John D. McPherson Jessica K. Miller Victor Moreno Xinmeng Jasmine Mu Reiko Nishihara Nickolas Papadopoulos Danielle Pasternack Michael J. Quist Adilya Rafikova Emma E. G. Reid Eve Shinbrot Brian H. Shirts Lincoln D. Stein Cherie D. Teney Lee Timms Caroline Y. Um Bethany Van Guelpen Megan Van Tassel Xiaolong Wang David A. Wheeler Christina K. Yung Li Hsu Shuji Ogino Andrea Gsur Polly A. Newcomb Steven Gallinger Michael Hoffmeister Peter T. Campbell Stephen N. Thibodeau Wei Sun Thomas J. Hudson Ulrike Peters
author_facet	Syed H. Zaidi Tabitha A. Harrison Amanda I. Phipps Robert Steinfelder Quang M. Trinh Conghui Qu Barbara L. Banbury Peter Georgeson Catherine S. Grasso Marios Giannakis Jeremy B. Adams Elizabeth Alwers Efrat L. Amitay Richard T. Barfield Sonja I. Berndt Ivan Borozan Hermann Brenner Stefanie Brezina Daniel D. Buchanan Yin Cao Andrew T. Chan Jenny Chang-Claude Charles M. Connolly David A. Drew Alton Brad Farris Jane C. Figueiredo Amy J. French Charles S. Fuchs Levi A. Garraway Steve Gruber Mark A. Guinter Stanley R. Hamilton Sophia Harlid Lawrence E. Heisler Akihisa Hidaka John L. Hopper Wen-Yi Huang Jeroen R. Huyghe Mark A. Jenkins Paul M. Krzyzanowski Mathieu Lemire Yi Lin Xuemei Luo Elaine R. Mardis John D. McPherson Jessica K. Miller Victor Moreno Xinmeng Jasmine Mu Reiko Nishihara Nickolas Papadopoulos Danielle Pasternack Michael J. Quist Adilya Rafikova Emma E. G. Reid Eve Shinbrot Brian H. Shirts Lincoln D. Stein Cherie D. Teney Lee Timms Caroline Y. Um Bethany Van Guelpen Megan Van Tassel Xiaolong Wang David A. Wheeler Christina K. Yung Li Hsu Shuji Ogino Andrea Gsur Polly A. Newcomb Steven Gallinger Michael Hoffmeister Peter T. Campbell Stephen N. Thibodeau Wei Sun Thomas J. Hudson Ulrike Peters
author_sort	Syed H. Zaidi
title	Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
title_short	Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
title_full	Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
title_fullStr	Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
title_full_unstemmed	Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
title_sort	landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a09dab8e99d844a6a6258b23214b612c
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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

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