Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer

Colorectal cancer (CRC) is one of the most common malignancies of the digestive system. Recent studies have revealed the importance of RNA-binding proteins (RBPs) in tumorigenesis, but their role in CRC remains unclear. The present study systematically analyzed the relationships between RBPs and CRC...

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Autores principales:	Xiao-fen Bai, Jing-wen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/a09f6492155b4d528a9a239d6e185d49
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spelling	oai:doaj.org-article:a09f6492155b4d528a9a239d6e185d492021-11-15T01:19:28ZIdentification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer2314-614110.1155/2021/7114445https://doaj.org/article/a09f6492155b4d528a9a239d6e185d492021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7114445https://doaj.org/toc/2314-6141Colorectal cancer (CRC) is one of the most common malignancies of the digestive system. Recent studies have revealed the importance of RNA-binding proteins (RBPs) in tumorigenesis, but their role in CRC remains unclear. The present study systematically analyzed the relationships between RBPs and CRC using data from The Cancer Genome Atlas. We detected 483 differentially expressed RBPs and identified a series of pathways and processes using GO (Gene Ontology) analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis. Analyzing protein–protein interactions and modules identified the edges and modules of RBPs. Univariate and multivariate Cox regression analyses were then used to construct a prognostic model that included 13 RBPs. Survival analyses indicated that the overall survival (OS) was significantly lower for CRC patients in the high-risk group than for those in the low-risk group, and that high risk scores were associated with poor OS. Finally, we constructed a nomogram that included 13 RBPs for calculating the estimated survival probabilities of CRC patients at 1, 2, and 3 years. Calibration plots indicated good conformity between the predicted and observed outcomes. This study has revealed that the expression of RBPs differs between CRC and normal tissues. A prognostic model based on 13 RBP coding genes has been developed that can provide independent prognoses of CRC.Xiao-fen BaiJing-wen LiuHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Xiao-fen Bai Jing-wen Liu Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
description	Colorectal cancer (CRC) is one of the most common malignancies of the digestive system. Recent studies have revealed the importance of RNA-binding proteins (RBPs) in tumorigenesis, but their role in CRC remains unclear. The present study systematically analyzed the relationships between RBPs and CRC using data from The Cancer Genome Atlas. We detected 483 differentially expressed RBPs and identified a series of pathways and processes using GO (Gene Ontology) analysis and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis. Analyzing protein–protein interactions and modules identified the edges and modules of RBPs. Univariate and multivariate Cox regression analyses were then used to construct a prognostic model that included 13 RBPs. Survival analyses indicated that the overall survival (OS) was significantly lower for CRC patients in the high-risk group than for those in the low-risk group, and that high risk scores were associated with poor OS. Finally, we constructed a nomogram that included 13 RBPs for calculating the estimated survival probabilities of CRC patients at 1, 2, and 3 years. Calibration plots indicated good conformity between the predicted and observed outcomes. This study has revealed that the expression of RBPs differs between CRC and normal tissues. A prognostic model based on 13 RBP coding genes has been developed that can provide independent prognoses of CRC.
format	article
author	Xiao-fen Bai Jing-wen Liu
author_facet	Xiao-fen Bai Jing-wen Liu
author_sort	Xiao-fen Bai
title	Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
title_short	Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
title_full	Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
title_fullStr	Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
title_full_unstemmed	Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer
title_sort	identification of rna-binding proteins with prognostic prediction in colorectal cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/a09f6492155b4d528a9a239d6e185d49
work_keys_str_mv	AT xiaofenbai identificationofrnabindingproteinswithprognosticpredictionincolorectalcancer AT jingwenliu identificationofrnabindingproteinswithprognosticpredictionincolorectalcancer
_version_	1718428939771183104

Identification of RNA-Binding Proteins with Prognostic Prediction in Colorectal Cancer

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