miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Anne-Marie Givel, Yann Kieffer, Alix Scholer-Dahirel, Philemon Sirven, Melissa Cardon, Floriane Pelon, Ilaria Magagna, Géraldine Gentric, Ana Costa, Claire Bonneau, Virginie Mieulet, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a09f89d7e4cd4d8ebd1d78403faf2e10
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a09f89d7e4cd4d8ebd1d78403faf2e10
record_format dspace
spelling oai:doaj.org-article:a09f89d7e4cd4d8ebd1d78403faf2e102021-12-02T16:56:36ZmiR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers10.1038/s41467-018-03348-z2041-1723https://doaj.org/article/a09f89d7e4cd4d8ebd1d78403faf2e102018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03348-zhttps://doaj.org/toc/2041-1723Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.Anne-Marie GivelYann KiefferAlix Scholer-DahirelPhilemon SirvenMelissa CardonFloriane PelonIlaria MagagnaGéraldine GentricAna CostaClaire BonneauVirginie MieuletAnne Vincent-SalomonFatima Mechta-GrigoriouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
description Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.
format article
author Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
author_facet Anne-Marie Givel
Yann Kieffer
Alix Scholer-Dahirel
Philemon Sirven
Melissa Cardon
Floriane Pelon
Ilaria Magagna
Géraldine Gentric
Ana Costa
Claire Bonneau
Virginie Mieulet
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
author_sort Anne-Marie Givel
title miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_short miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_full miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_fullStr miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_full_unstemmed miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
title_sort mir200-regulated cxcl12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a09f89d7e4cd4d8ebd1d78403faf2e10
work_keys_str_mv AT annemariegivel mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT yannkieffer mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT alixscholerdahirel mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT philemonsirven mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT melissacardon mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT florianepelon mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT ilariamagagna mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT geraldinegentric mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT anacosta mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT clairebonneau mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT virginiemieulet mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT annevincentsalomon mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
AT fatimamechtagrigoriou mir200regulatedcxcl12bpromotesfibroblastheterogeneityandimmunosuppressioninovariancancers
_version_ 1718382816327106560

Ejemplares similares