miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL...

Full description

Saved in:
Bibliographic Details
Main Authors: Anne-Marie Givel, Yann Kieffer, Alix Scholer-Dahirel, Philemon Sirven, Melissa Cardon, Floriane Pelon, Ilaria Magagna, Géraldine Gentric, Ana Costa, Claire Bonneau, Virginie Mieulet, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/a09f89d7e4cd4d8ebd1d78403faf2e10
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items