Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.

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Auteurs principaux:	Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a09faa777f7149ee893741429bd2620e
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spelling	oai:doaj.org-article:a09faa777f7149ee893741429bd2620e2021-12-02T15:33:58ZPathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii10.1038/s41467-018-03991-62041-1723https://doaj.org/article/a09faa777f7149ee893741429bd2620e2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03991-6https://doaj.org/toc/2041-1723Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.Ewa BielskaMarta Arch SisquellaMaha AldeiegCharlotte BirchEloise J. O’DonoghueRobin C. MayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
description	Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.
format	article
author	Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May
author_facet	Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May
author_sort	Ewa Bielska
title	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_short	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_full	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_fullStr	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_full_unstemmed	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_sort	pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen cryptococcus gattii
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a09faa777f7149ee893741429bd2620e
work_keys_str_mv	AT ewabielska pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii AT martaarchsisquella pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii AT mahaaldeieg pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii AT charlottebirch pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii AT eloisejodonoghue pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii AT robincmay pathogenderivedextracellularvesiclesmediatevirulenceinthefatalhumanpathogencryptococcusgattii
_version_	1718386981404147712

Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

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