Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.

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Autores principales:	Ewa Bielska, Marta Arch Sisquella, Maha Aldeieg, Charlotte Birch, Eloise J. O’Donoghue, Robin C. May
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a09faa777f7149ee893741429bd2620e
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spelling	oai:doaj.org-article:a09faa777f7149ee893741429bd2620e2021-12-02T15:33:58ZPathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii10.1038/s41467-018-03991-62041-1723https://doaj.org/article/a09faa777f7149ee893741429bd2620e2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03991-6https://doaj.org/toc/2041-1723Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.Ewa BielskaMarta Arch SisquellaMaha AldeiegCharlotte BirchEloise J. O’DonoghueRobin C. MayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
description	Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.
format	article
author	Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May
author_facet	Ewa Bielska Marta Arch Sisquella Maha Aldeieg Charlotte Birch Eloise J. O’Donoghue Robin C. May
author_sort	Ewa Bielska
title	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_short	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_full	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_fullStr	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_full_unstemmed	Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
title_sort	pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen cryptococcus gattii
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a09faa777f7149ee893741429bd2620e
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Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

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