Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease

Objective: Mitochondrial disease is a multisystem disorder resulting from mitochondrial dysfunction. Although musculoskeletal system is vulnerable to mitochondrial dysfunction, little information is available on orthopedic issues such as hip displacement and scoliosis in patients with mitochondrial...

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Autores principales:	Sungmin Kim, Young-Mock Lee, Kun-Bo Park, Minsu Lee, Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mitochondrial disease mitochondrial myopathy Leigh syndrome MELAS syndrome hip displacement Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/a0a032ae5c1c4799be1aca2d97f3c49d
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spelling	oai:doaj.org-article:a0a032ae5c1c4799be1aca2d97f3c49d2021-11-04T06:45:23ZPoint Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease2296-236010.3389/fped.2021.637240https://doaj.org/article/a0a032ae5c1c4799be1aca2d97f3c49d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.637240/fullhttps://doaj.org/toc/2296-2360Objective: Mitochondrial disease is a multisystem disorder resulting from mitochondrial dysfunction. Although musculoskeletal system is vulnerable to mitochondrial dysfunction, little information is available on orthopedic issues such as hip displacement and scoliosis in patients with mitochondrial disease. We aimed to examine the point prevalence of hip displacement and investigate the associated factors in patients with mitochondrial disease.Methods: We retrospectively reviewed the medical records and plain radiographs of patients diagnosed with mitochondrial disease between January 2006 and January 2019 at a single institution. Data, including patient age, sex, follow-up duration, syndromic diagnosis, and gross motor function were collected. Migration percentage was measured on the radiographs. The clinical and radiologic variables were compared between patients classified according to the presence of hip displacement and motor function level.Results: We included 225 patients (135 men, 90 women). The mean age at the latest follow-up was 11.1 years, and the mean follow-up duration was 7.0 years. Hip displacement was noted in 70 (31.1%) patients. The proportion of patients with Leigh disease (p = 0.007) and the ratio of non-ambulators (p < 0.001) were higher among patients with hip displacement. The proportion of patients with Leigh disease was higher in the non-ambulators than the ambulators.Conclusion: One-third of patients with mitochondrial disease developed hip displacement. Hip displacement was more common in non-ambulators or patients with hypertonia. Careful and serial monitoring for hip problems is required for non-ambulatory patients with mitochondrial disease who have increased muscle tone.Sungmin KimYoung-Mock LeeKun-Bo ParkMinsu LeeHoon ParkFrontiers Media S.A.articlemitochondrial diseasemitochondrial myopathyLeigh syndromeMELAS syndromehip displacementPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondrial disease mitochondrial myopathy Leigh syndrome MELAS syndrome hip displacement Pediatrics RJ1-570
spellingShingle	mitochondrial disease mitochondrial myopathy Leigh syndrome MELAS syndrome hip displacement Pediatrics RJ1-570 Sungmin Kim Young-Mock Lee Kun-Bo Park Minsu Lee Hoon Park Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
description	Objective: Mitochondrial disease is a multisystem disorder resulting from mitochondrial dysfunction. Although musculoskeletal system is vulnerable to mitochondrial dysfunction, little information is available on orthopedic issues such as hip displacement and scoliosis in patients with mitochondrial disease. We aimed to examine the point prevalence of hip displacement and investigate the associated factors in patients with mitochondrial disease.Methods: We retrospectively reviewed the medical records and plain radiographs of patients diagnosed with mitochondrial disease between January 2006 and January 2019 at a single institution. Data, including patient age, sex, follow-up duration, syndromic diagnosis, and gross motor function were collected. Migration percentage was measured on the radiographs. The clinical and radiologic variables were compared between patients classified according to the presence of hip displacement and motor function level.Results: We included 225 patients (135 men, 90 women). The mean age at the latest follow-up was 11.1 years, and the mean follow-up duration was 7.0 years. Hip displacement was noted in 70 (31.1%) patients. The proportion of patients with Leigh disease (p = 0.007) and the ratio of non-ambulators (p < 0.001) were higher among patients with hip displacement. The proportion of patients with Leigh disease was higher in the non-ambulators than the ambulators.Conclusion: One-third of patients with mitochondrial disease developed hip displacement. Hip displacement was more common in non-ambulators or patients with hypertonia. Careful and serial monitoring for hip problems is required for non-ambulatory patients with mitochondrial disease who have increased muscle tone.
format	article
author	Sungmin Kim Young-Mock Lee Kun-Bo Park Minsu Lee Hoon Park
author_facet	Sungmin Kim Young-Mock Lee Kun-Bo Park Minsu Lee Hoon Park
author_sort	Sungmin Kim
title	Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
title_short	Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
title_full	Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
title_fullStr	Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
title_full_unstemmed	Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease
title_sort	point prevalence and associated factors of hip displacement in pediatric patients with mitochondrial disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a0a032ae5c1c4799be1aca2d97f3c49d
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Point Prevalence and Associated Factors of Hip Displacement in Pediatric Patients With Mitochondrial Disease

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