β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling

DeNies et al. identify a new mechanism of intracellular GPCR signalling. Using CXC chemokine receptor 4 (CXCR4) as a model, they show that upon stimulation with receptor agonists that not only plasma membrane-localized receptors, but also intracellular CXCR4 molecules are post-translationally modifi...

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Autores principales:	Maxwell S. DeNies, Alan V. Smrcka, Santiago Schnell, Allen P. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a0a094837ce448838dbe265fd50519a0
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spelling	oai:doaj.org-article:a0a094837ce448838dbe265fd50519a02021-12-02T13:33:58Zβ-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling10.1038/s42003-020-01510-22399-3642https://doaj.org/article/a0a094837ce448838dbe265fd50519a02020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01510-2https://doaj.org/toc/2399-3642DeNies et al. identify a new mechanism of intracellular GPCR signalling. Using CXC chemokine receptor 4 (CXCR4) as a model, they show that upon stimulation with receptor agonists that not only plasma membrane-localized receptors, but also intracellular CXCR4 molecules are post-translationally modified and regulate transcription. This study suggests that a small pool of plasma membrane-localized GPCRs can activate internal receptor-dependent signaling, and that β-arrestin-1 mediates this activation.Maxwell S. DeNiesAlan V. SmrckaSantiago SchnellAllen P. LiuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maxwell S. DeNies Alan V. Smrcka Santiago Schnell Allen P. Liu β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
description	DeNies et al. identify a new mechanism of intracellular GPCR signalling. Using CXC chemokine receptor 4 (CXCR4) as a model, they show that upon stimulation with receptor agonists that not only plasma membrane-localized receptors, but also intracellular CXCR4 molecules are post-translationally modified and regulate transcription. This study suggests that a small pool of plasma membrane-localized GPCRs can activate internal receptor-dependent signaling, and that β-arrestin-1 mediates this activation.
format	article
author	Maxwell S. DeNies Alan V. Smrcka Santiago Schnell Allen P. Liu
author_facet	Maxwell S. DeNies Alan V. Smrcka Santiago Schnell Allen P. Liu
author_sort	Maxwell S. DeNies
title	β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
title_short	β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
title_full	β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
title_fullStr	β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
title_full_unstemmed	β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
title_sort	β-arrestin mediates communication between plasma membrane and intracellular gpcrs to regulate signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a0a094837ce448838dbe265fd50519a0
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β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling

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