Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

Development of bacterial resistance to an antibiotic can lead to collateral sensitivity to another drug. Here, the authors study collateral sensitivity conferred by mutations in the horizontally acquired β-lactamase CTX-M-15, and identify antibiotic combinations that constrain the evolution of resis...

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Auteurs principaux:	Carola E. H. Rosenkilde, Christian Munck, Andreas Porse, Marius Linkevicius, Dan I. Andersson, Morten O. A. Sommer
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a0a1a4e12b5342fc952264aa461d8831
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id	oai:doaj.org-article:a0a1a4e12b5342fc952264aa461d8831
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spelling	oai:doaj.org-article:a0a1a4e12b5342fc952264aa461d88312021-12-02T15:35:54ZCollateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase10.1038/s41467-019-08529-y2041-1723https://doaj.org/article/a0a1a4e12b5342fc952264aa461d88312019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08529-yhttps://doaj.org/toc/2041-1723Development of bacterial resistance to an antibiotic can lead to collateral sensitivity to another drug. Here, the authors study collateral sensitivity conferred by mutations in the horizontally acquired β-lactamase CTX-M-15, and identify antibiotic combinations that constrain the evolution of resistance.Carola E. H. RosenkildeChristian MunckAndreas PorseMarius LinkeviciusDan I. AnderssonMorten O. A. SommerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carola E. H. Rosenkilde Christian Munck Andreas Porse Marius Linkevicius Dan I. Andersson Morten O. A. Sommer Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
description	Development of bacterial resistance to an antibiotic can lead to collateral sensitivity to another drug. Here, the authors study collateral sensitivity conferred by mutations in the horizontally acquired β-lactamase CTX-M-15, and identify antibiotic combinations that constrain the evolution of resistance.
format	article
author	Carola E. H. Rosenkilde Christian Munck Andreas Porse Marius Linkevicius Dan I. Andersson Morten O. A. Sommer
author_facet	Carola E. H. Rosenkilde Christian Munck Andreas Porse Marius Linkevicius Dan I. Andersson Morten O. A. Sommer
author_sort	Carola E. H. Rosenkilde
title	Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
title_short	Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
title_full	Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
title_fullStr	Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
title_full_unstemmed	Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase
title_sort	collateral sensitivity constrains resistance evolution of the ctx-m-15 β-lactamase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a0a1a4e12b5342fc952264aa461d8831
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Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

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