Innovative therapeutic strategy using prostaglandin I2 agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension

Innovative therapeutic strategy using prostaglandin I2 agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension

Abstract Clinical outcomes of pulmonary arterial hypertension (PAH) may be improved using targeted delivery system. We investigated the efficacy of ONO1301 (prostacyclin agonist) nanospheres (ONONS) in Sugen5416/hypoxia rat models of PAH. The rats were injected with saline (control) or ONONS (n = 10...

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Autores principales: Tomomitsu Kanaya, Shigeru Miyagawa, Takuji Kawamura, Yoshiki Sakai, Kenta Masada, Nobutoshi Nawa, Hidekazu Ishida, Jun Narita, Koichi Toda, Toru Kuratani, Yoshiki Sawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a0a7092285df41cc9b0a00ae9053c163
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