Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism
ObjectiveTo assess the efficacy and safety of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperparathyroidism (PHPT), and to investigate whether MWA can improve the bone turnover and renal function.MethodsA total of 20 consecutive PHPT patients with 21 parathyroid lesions...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a0a88f7126a84cc492517e002492edc92021-12-02T00:33:30ZBone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism1664-239210.3389/fendo.2021.782050https://doaj.org/article/a0a88f7126a84cc492517e002492edc92021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.782050/fullhttps://doaj.org/toc/1664-2392ObjectiveTo assess the efficacy and safety of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperparathyroidism (PHPT), and to investigate whether MWA can improve the bone turnover and renal function.MethodsA total of 20 consecutive PHPT patients with 21 parathyroid lesions treated with MWA in our center from May 2019 to March 2021 were recruited in this study. Serum parathyroid hormone (PTH), calcium and phosphorus levels before MWA and at 20 minutes, 4 hours, 1 day, 3 months, 6 months and 12 months after MWA were measured. Bone turnover biomarkers, renal function and lesion volume with volume reduction rate (VRR) before MWA and at the last follow-up were compared. Any complication related with MWA was evaluated. The technical and clinical success rates of MWA in the treatment of PHPT were calculated. Clinical success was defined as normal serum PTH and calcium without PHPT-associated manifestations at more than 6 months after ablation. Technical success was defined as complete ablation indicated by immediate postoperative contrast-enhanced ultrasound.ResultsThe serum PTH, calcium and phosphorus levels at their respective follow-up time points dropped significantly after MWA (P <0.05). The volume of parathyroid lesions at the final examination was significantly reduced, compared with pre-ablation volume (P <0.001), with a median VRR reaching 89%. The technical and clinical success rates were 100% and 63.6%, respectively. Substantial changes of bone turnover biomarkers were observed before and after MWA (P <0.05), but the differences in renal function were not statistically significant. No major complications were reported in all cases. Pre-MWA serum PTH, lesion volume, maximum diameter of lesion and ablation time were significantly different between patients with successful and failed MWA.ConclusionsPHPT can be effectively and safely treated by ultrasound-guided MWA, as proven by drop in serum PTH and reduction in the volume of parathyroid adenomas. Besides, MWA can impede bone remodeling to suppress hyperparathyroidism in the condition of PHPT.Wenjing NiYue YuanXiaoqiu ChuGuofang ChenGuofang ChenXue HanJie LiXinping WuJianhua WangChao LiuChao LiuShuhang XuFrontiers Media S.A.articleprimary hyperparathyroidismmicrowave ablationthermal ablationbone turnoverrenal functionDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
primary hyperparathyroidism microwave ablation thermal ablation bone turnover renal function Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
primary hyperparathyroidism microwave ablation thermal ablation bone turnover renal function Diseases of the endocrine glands. Clinical endocrinology RC648-665 Wenjing Ni Yue Yuan Xiaoqiu Chu Guofang Chen Guofang Chen Xue Han Jie Li Xinping Wu Jianhua Wang Chao Liu Chao Liu Shuhang Xu Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| description |
ObjectiveTo assess the efficacy and safety of ultrasound-guided microwave ablation (MWA) in the treatment of primary hyperparathyroidism (PHPT), and to investigate whether MWA can improve the bone turnover and renal function.MethodsA total of 20 consecutive PHPT patients with 21 parathyroid lesions treated with MWA in our center from May 2019 to March 2021 were recruited in this study. Serum parathyroid hormone (PTH), calcium and phosphorus levels before MWA and at 20 minutes, 4 hours, 1 day, 3 months, 6 months and 12 months after MWA were measured. Bone turnover biomarkers, renal function and lesion volume with volume reduction rate (VRR) before MWA and at the last follow-up were compared. Any complication related with MWA was evaluated. The technical and clinical success rates of MWA in the treatment of PHPT were calculated. Clinical success was defined as normal serum PTH and calcium without PHPT-associated manifestations at more than 6 months after ablation. Technical success was defined as complete ablation indicated by immediate postoperative contrast-enhanced ultrasound.ResultsThe serum PTH, calcium and phosphorus levels at their respective follow-up time points dropped significantly after MWA (P <0.05). The volume of parathyroid lesions at the final examination was significantly reduced, compared with pre-ablation volume (P <0.001), with a median VRR reaching 89%. The technical and clinical success rates were 100% and 63.6%, respectively. Substantial changes of bone turnover biomarkers were observed before and after MWA (P <0.05), but the differences in renal function were not statistically significant. No major complications were reported in all cases. Pre-MWA serum PTH, lesion volume, maximum diameter of lesion and ablation time were significantly different between patients with successful and failed MWA.ConclusionsPHPT can be effectively and safely treated by ultrasound-guided MWA, as proven by drop in serum PTH and reduction in the volume of parathyroid adenomas. Besides, MWA can impede bone remodeling to suppress hyperparathyroidism in the condition of PHPT. |
| format |
article |
| author |
Wenjing Ni Yue Yuan Xiaoqiu Chu Guofang Chen Guofang Chen Xue Han Jie Li Xinping Wu Jianhua Wang Chao Liu Chao Liu Shuhang Xu |
| author_facet |
Wenjing Ni Yue Yuan Xiaoqiu Chu Guofang Chen Guofang Chen Xue Han Jie Li Xinping Wu Jianhua Wang Chao Liu Chao Liu Shuhang Xu |
| author_sort |
Wenjing Ni |
| title |
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| title_short |
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| title_full |
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| title_fullStr |
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| title_full_unstemmed |
Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism |
| title_sort |
bone turnover markers in response to ultrasound-guided microwave ablation for primary hyperparathyroidism |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a0a88f7126a84cc492517e002492edc9 |
| work_keys_str_mv |
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1718403694981021696 |