GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway

This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to the poor outcomes. Furthermore, biological func...

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Autores principales:	Wang Jian, Xu Min, Li Dan-Dan, Abudukelimu Wujikenayi, Zhou Xiu-Hong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	lung adenocarcinoma gpr37 tgf-β/smad pathway Medicine R
Acceso en línea:	https://doaj.org/article/a0aabd7c88314fafb5c12d5aaa91555a
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spelling	oai:doaj.org-article:a0aabd7c88314fafb5c12d5aaa91555a2021-12-05T14:10:53ZGPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway2391-546310.1515/med-2021-0011https://doaj.org/article/a0aabd7c88314fafb5c12d5aaa91555a2020-12-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0011https://doaj.org/toc/2391-5463This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to the poor outcomes. Furthermore, biological function experiments in vitro were utilized to assess whether GPR37 impacts malignant phenotype of LUAD cells. Gain- or loss-of-function assays indicated that the upregulation of GPR37 contributed to improving the proliferation, migration, and invasion of LUAD cells in vitro, while knockdown of GPR37 can inhibit the malignant biological behaviors. Then, we found that depletion of GPR37 resulted in a decrease in the expression of TGF-β1 as well as the extents of Smad2 and Smad3 phosphorylation, while overexpression of GPR37 presented opposite outcomes. Altogether, our findings indicated that GPR37 is a potential oncogene of LUAD, and its promoting effects on the malignant progression of LUAD may be realized via TGF-β/Smad pathway.Wang JianXu MinLi Dan-DanAbudukelimu WujikenayiZhou Xiu-HongDe Gruyterarticlelung adenocarcinomagpr37tgf-β/smad pathwayMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 024-032 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma gpr37 tgf-β/smad pathway Medicine R
spellingShingle	lung adenocarcinoma gpr37 tgf-β/smad pathway Medicine R Wang Jian Xu Min Li Dan-Dan Abudukelimu Wujikenayi Zhou Xiu-Hong GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
description	This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to the poor outcomes. Furthermore, biological function experiments in vitro were utilized to assess whether GPR37 impacts malignant phenotype of LUAD cells. Gain- or loss-of-function assays indicated that the upregulation of GPR37 contributed to improving the proliferation, migration, and invasion of LUAD cells in vitro, while knockdown of GPR37 can inhibit the malignant biological behaviors. Then, we found that depletion of GPR37 resulted in a decrease in the expression of TGF-β1 as well as the extents of Smad2 and Smad3 phosphorylation, while overexpression of GPR37 presented opposite outcomes. Altogether, our findings indicated that GPR37 is a potential oncogene of LUAD, and its promoting effects on the malignant progression of LUAD may be realized via TGF-β/Smad pathway.
format	article
author	Wang Jian Xu Min Li Dan-Dan Abudukelimu Wujikenayi Zhou Xiu-Hong
author_facet	Wang Jian Xu Min Li Dan-Dan Abudukelimu Wujikenayi Zhou Xiu-Hong
author_sort	Wang Jian
title	GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
title_short	GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
title_full	GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
title_fullStr	GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
title_full_unstemmed	GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
title_sort	gpr37 promotes the malignancy of lung adenocarcinoma via tgf-β/smad pathway
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/a0aabd7c88314fafb5c12d5aaa91555a
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GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway

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