Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography

Abstract We performed a prospective, longitudinal study to investigate the association between the preoperative intrascleral vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) and surgical outcomes of trabecular meshwork-targeted micro- or minimally inva...

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Autores principales:	Yoko Okamoto, Tadamichi Akagi, Takanori Kameda, Kenji Suda, Masahiro Miyake, Hanako Ohashi Ikeda, Shogo Numa, Shin Kadomoto, Akihito Uji, Akitaka Tsujikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0ab6677bd89400b9e078213f359a401
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spelling	oai:doaj.org-article:a0ab6677bd89400b9e078213f359a4012021-12-02T19:12:25ZPrediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography10.1038/s41598-021-97290-82045-2322https://doaj.org/article/a0ab6677bd89400b9e078213f359a4012021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97290-8https://doaj.org/toc/2045-2322Abstract We performed a prospective, longitudinal study to investigate the association between the preoperative intrascleral vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) and surgical outcomes of trabecular meshwork-targeted micro- or minimally invasive glaucoma surgery (MIGS). We included 37 patients with primary open-angle glaucoma. Preoperative AS-OCTA images of the sclero-conjunctiva of the nasal corneal limbus were acquired in the superficial (conjunctival) and deep (intrascleral) layers. The vessel densities (VDs) of each layer were measured separately in the entire area, limbal side, and fornix area. Surgical success was determined by postoperative intraocular pressure (IOP) and IOP reduction. Twenty-three and 14 eyes were classified as having successful and unsuccessful outcomes, respectively. The deep VDs of the entire area and fornix area were significantly lower in the successful group (P = 0.031 and P = 0.009). The success rate was significantly higher for eyes with a lower deep VD than for eyes with a higher deep VD. A greater IOP reduction was significantly associated with lower deep VD in the fornix area (P = 0.022) and higher preoperative IOP (P < 0.001). These results indicate that intrascleral vasculature assessed using preoperative AS-OCTA was negatively correlated with surgical success and IOP reduction resulting from trabecular meshwork-targeted MIGS. AS-OCTA images might help predict MIGS outcomes.Yoko OkamotoTadamichi AkagiTakanori KamedaKenji SudaMasahiro MiyakeHanako Ohashi IkedaShogo NumaShin KadomotoAkihito UjiAkitaka TsujikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoko Okamoto Tadamichi Akagi Takanori Kameda Kenji Suda Masahiro Miyake Hanako Ohashi Ikeda Shogo Numa Shin Kadomoto Akihito Uji Akitaka Tsujikawa Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
description	Abstract We performed a prospective, longitudinal study to investigate the association between the preoperative intrascleral vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) and surgical outcomes of trabecular meshwork-targeted micro- or minimally invasive glaucoma surgery (MIGS). We included 37 patients with primary open-angle glaucoma. Preoperative AS-OCTA images of the sclero-conjunctiva of the nasal corneal limbus were acquired in the superficial (conjunctival) and deep (intrascleral) layers. The vessel densities (VDs) of each layer were measured separately in the entire area, limbal side, and fornix area. Surgical success was determined by postoperative intraocular pressure (IOP) and IOP reduction. Twenty-three and 14 eyes were classified as having successful and unsuccessful outcomes, respectively. The deep VDs of the entire area and fornix area were significantly lower in the successful group (P = 0.031 and P = 0.009). The success rate was significantly higher for eyes with a lower deep VD than for eyes with a higher deep VD. A greater IOP reduction was significantly associated with lower deep VD in the fornix area (P = 0.022) and higher preoperative IOP (P < 0.001). These results indicate that intrascleral vasculature assessed using preoperative AS-OCTA was negatively correlated with surgical success and IOP reduction resulting from trabecular meshwork-targeted MIGS. AS-OCTA images might help predict MIGS outcomes.
format	article
author	Yoko Okamoto Tadamichi Akagi Takanori Kameda Kenji Suda Masahiro Miyake Hanako Ohashi Ikeda Shogo Numa Shin Kadomoto Akihito Uji Akitaka Tsujikawa
author_facet	Yoko Okamoto Tadamichi Akagi Takanori Kameda Kenji Suda Masahiro Miyake Hanako Ohashi Ikeda Shogo Numa Shin Kadomoto Akihito Uji Akitaka Tsujikawa
author_sort	Yoko Okamoto
title	Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
title_short	Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
title_full	Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
title_fullStr	Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
title_full_unstemmed	Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography
title_sort	prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment oct angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a0ab6677bd89400b9e078213f359a401
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Prediction of trabecular meshwork-targeted micro-invasive glaucoma surgery outcomes using anterior segment OCT angiography

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