AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS

Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through el...

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Autores principales:	David Uriel Ayllón Álvarez, Mariana Neri Calixto, César Humberto Aparicio Albarrán, Hugo Mendieta Zerón
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	amyotrophic lateral sclerosis autologous stem cell transplantation puerperium surface-fixation method Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a0b0fe17bec94c87a977d434461622a3
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spelling	oai:doaj.org-article:a0b0fe17bec94c87a977d434461622a32021-11-24T07:45:14ZAUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS10.21776/ub.mnj.2021.007.02.122407-67242442-5001https://doaj.org/article/a0b0fe17bec94c87a977d434461622a32021-07-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/548https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through electromyography. After spontaneous abortion and 88 days without clinical improvement and dependent on mechanical ventilation, treatment with autologous stem cell transplantation and immunomodulation was decided upon for the patient. Methods: The patient received a daily subcutaneous (s.c.) dose of 300 μg human Granulocyte-Colony stimulating factor for a period of 3 days. Peripheral blood mononuclear cells were isolated by leukapheresis. These cells were self-transplanted to the patient 5 cc via lumbar puncture and 5 cc intravenously (i.v.). The immunomodulation treatment was based on the surface-fixation method. Results: The patient remained hospitalized for an additional 249 days, at which time when she was contrareferred to a secondary-level health institution. Conclusion: A treatment scheme combining ASCT (Autologous Stem Cell Transplantation) and immunomodulation, based on the surface-fixation method, could be an option to get a large period of no progression stage in ALS.David Uriel Ayllón ÁlvarezMariana Neri CalixtoCésar Humberto Aparicio AlbarránHugo Mendieta ZerónUniversity of Brawijayaarticleamyotrophic lateral sclerosisautologous stem cell transplantationpuerperiumsurface-fixation methodMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 2, Pp 140-145 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	amyotrophic lateral sclerosis autologous stem cell transplantation puerperium surface-fixation method Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	amyotrophic lateral sclerosis autologous stem cell transplantation puerperium surface-fixation method Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
description	Background: Amyotrophic lateral sclerosis (ALS) is a rare chronic degenerative disease. The only approved treatment, Riluzole, is not available and is not economically affordable for most patients. Objective: To report here a case of a pregnant woman 27 years of age with ALS, confirmed through electromyography. After spontaneous abortion and 88 days without clinical improvement and dependent on mechanical ventilation, treatment with autologous stem cell transplantation and immunomodulation was decided upon for the patient. Methods: The patient received a daily subcutaneous (s.c.) dose of 300 μg human Granulocyte-Colony stimulating factor for a period of 3 days. Peripheral blood mononuclear cells were isolated by leukapheresis. These cells were self-transplanted to the patient 5 cc via lumbar puncture and 5 cc intravenously (i.v.). The immunomodulation treatment was based on the surface-fixation method. Results: The patient remained hospitalized for an additional 249 days, at which time when she was contrareferred to a secondary-level health institution. Conclusion: A treatment scheme combining ASCT (Autologous Stem Cell Transplantation) and immunomodulation, based on the surface-fixation method, could be an option to get a large period of no progression stage in ALS.
format	article
author	David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón
author_facet	David Uriel Ayllón Álvarez Mariana Neri Calixto César Humberto Aparicio Albarrán Hugo Mendieta Zerón
author_sort	David Uriel Ayllón Álvarez
title	AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
title_short	AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
title_full	AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
title_fullStr	AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
title_full_unstemmed	AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS
title_sort	autologous stem cell transplantation and immunomodulation in amyotrophic lateral sclerosis
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/a0b0fe17bec94c87a977d434461622a3
work_keys_str_mv	AT davidurielayllonalvarez autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT mariananericalixto autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT cesarhumbertoaparicioalbarran autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis AT hugomendietazeron autologousstemcelltransplantationandimmunomodulationinamyotrophiclateralsclerosis
_version_	1718415874778464256

AUTOLOGOUS STEM CELL TRANSPLANTATION AND IMMUNOMODULATION IN AMYOTROPHIC LATERAL SCLEROSIS

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