Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease
The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, wh...
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Endocrinology Research Centre
2012
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oai:doaj.org-article:a0b7dc2b00c94888a3ecc8ecad6405f82021-11-14T09:00:17ZInсretin-based therapy in patients with type 2 diabetes and chronic kidney disease2072-03512072-037810.14341/2072-0351-6087https://doaj.org/article/a0b7dc2b00c94888a3ecc8ecad6405f82012-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6087https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend.Minara Shamkhalovna ShamkhalovaMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlediabetes mellituschronic kidney diseasediabetic nephropathyincretin-based therapyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 3, Pp 59-66 (2012) |
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DOAJ |
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DOAJ |
| language |
EN RU |
| topic |
diabetes mellitus chronic kidney disease diabetic nephropathy incretin-based therapy Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
diabetes mellitus chronic kidney disease diabetic nephropathy incretin-based therapy Nutritional diseases. Deficiency diseases RC620-627 Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| description |
The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend. |
| format |
article |
| author |
Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_facet |
Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_sort |
Minara Shamkhalovna Shamkhalova |
| title |
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_short |
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_full |
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_fullStr |
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_full_unstemmed |
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_sort |
inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| publisher |
Endocrinology Research Centre |
| publishDate |
2012 |
| url |
https://doaj.org/article/a0b7dc2b00c94888a3ecc8ecad6405f8 |
| work_keys_str_mv |
AT minarashamkhalovnashamkhalova insretinbasedtherapyinpatientswithtype2diabetesandchronickidneydisease AT marinavladimirovnashestakova insretinbasedtherapyinpatientswithtype2diabetesandchronickidneydisease |
| _version_ |
1718429599662080000 |