DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS

Objective: To determine the frequency of normoglycemia (NG), prediabetes and diabetes mellitus (DM) among patients having impaired random glucose (IRG) and establish the optimum cutoff of impaired random glucose for the diagnosis of diabetes and prediabetes. Study Design: Cross sectional study. Plac...

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Autores principales:	Qurat Ul Ain Mustafa, Muhammad Amir, Muhammad Tanvir Sajid, Zujaja Hina Haroon, Aamir Ejaz, Naveed Asif
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	diabetes mellitus frequency glucose tolerance test prediabetes Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71iSuppl-1.3230 https://doaj.org/article/a0ba260ca1ad4feb86009e26292d9a00
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spelling	oai:doaj.org-article:a0ba260ca1ad4feb86009e26292d9a002021-12-02T19:11:53ZDETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUShttps://doi.org/10.51253/pafmj.v71iSuppl-1.32300030-96482411-8842https://doaj.org/article/a0ba260ca1ad4feb86009e26292d9a002021-01-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3230https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of normoglycemia (NG), prediabetes and diabetes mellitus (DM) among patients having impaired random glucose (IRG) and establish the optimum cutoff of impaired random glucose for the diagnosis of diabetes and prediabetes. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology Rawalpindi and Combined Military Hospital Quetta, from Nov 2016 to Nov 2018. Methodology: Healthy individuals of both genders undergoing investigation for diabetes mellitus were enrolled through non probability consecutive sampling while patients with diabetes, pregnant, hospitalized, using con-comitant medications (corticosteroids, immunosuppressive, chemotherapy) and those unable to complete oral glucose tolerance test (OGTT) were excluded. Random plasma glucose (RPG) was determined and patients having impaired random glucose underwent oral glucose tolerance test, analysis being done on ADVIA1800® using hexokinase methodology. Results: Among the 280 study participants, majority were female {156 (57.5%) vs 124 (44.3%) male}. Mean age in male and female patients was 33.625 ± 3.34 years vs 35.150 ± 2.79 years with p-value 0.50 while mean IRG was 7.12 ± 1.47 vs 6.90 ± 1.17 mmol/L respectively with p-value 0.16 (statistically insignificant). Oral glucose tolerance test results showed NG in 61.8% (173), prediabetes in 24.6% (69) while diabetes was found in 38 (13.6%) patients. Optimal impaired random glucose cutoff value for diagnosis of diabetes was found 7.45 mmol/L (AUC 0.956 [CI 0.927-0.984], p<0.001, sensitivity 94.7%, specificity 74.4%), however, same cut-off value showed impaired random glucose as fair diagnostic test for prediabetes (AUC 0.771 [CI 0.717-0.825], p<0.001, sensitivity 72.5%, specificity 77.3%). Conclusion: Random plasma glucose helps diagnose patients at risk of prediabetes and diabetes who may other-wise not be identified. Impaired random glucose ≥7.45 mmol/L was found optimal to initiate definitive testing.Qurat Ul Ain MustafaMuhammad AmirMuhammad Tanvir SajidZujaja Hina HaroonAamir EjazNaveed AsifArmy Medical College Rawalpindiarticlediabetes mellitusfrequencyglucose tolerance testprediabetesMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss SUPPL-1, Pp 261-267 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus frequency glucose tolerance test prediabetes Medicine R Medicine (General) R5-920
spellingShingle	diabetes mellitus frequency glucose tolerance test prediabetes Medicine R Medicine (General) R5-920 Qurat Ul Ain Mustafa Muhammad Amir Muhammad Tanvir Sajid Zujaja Hina Haroon Aamir Ejaz Naveed Asif DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
description	Objective: To determine the frequency of normoglycemia (NG), prediabetes and diabetes mellitus (DM) among patients having impaired random glucose (IRG) and establish the optimum cutoff of impaired random glucose for the diagnosis of diabetes and prediabetes. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology Rawalpindi and Combined Military Hospital Quetta, from Nov 2016 to Nov 2018. Methodology: Healthy individuals of both genders undergoing investigation for diabetes mellitus were enrolled through non probability consecutive sampling while patients with diabetes, pregnant, hospitalized, using con-comitant medications (corticosteroids, immunosuppressive, chemotherapy) and those unable to complete oral glucose tolerance test (OGTT) were excluded. Random plasma glucose (RPG) was determined and patients having impaired random glucose underwent oral glucose tolerance test, analysis being done on ADVIA1800® using hexokinase methodology. Results: Among the 280 study participants, majority were female {156 (57.5%) vs 124 (44.3%) male}. Mean age in male and female patients was 33.625 ± 3.34 years vs 35.150 ± 2.79 years with p-value 0.50 while mean IRG was 7.12 ± 1.47 vs 6.90 ± 1.17 mmol/L respectively with p-value 0.16 (statistically insignificant). Oral glucose tolerance test results showed NG in 61.8% (173), prediabetes in 24.6% (69) while diabetes was found in 38 (13.6%) patients. Optimal impaired random glucose cutoff value for diagnosis of diabetes was found 7.45 mmol/L (AUC 0.956 [CI 0.927-0.984], p<0.001, sensitivity 94.7%, specificity 74.4%), however, same cut-off value showed impaired random glucose as fair diagnostic test for prediabetes (AUC 0.771 [CI 0.717-0.825], p<0.001, sensitivity 72.5%, specificity 77.3%). Conclusion: Random plasma glucose helps diagnose patients at risk of prediabetes and diabetes who may other-wise not be identified. Impaired random glucose ≥7.45 mmol/L was found optimal to initiate definitive testing.
format	article
author	Qurat Ul Ain Mustafa Muhammad Amir Muhammad Tanvir Sajid Zujaja Hina Haroon Aamir Ejaz Naveed Asif
author_facet	Qurat Ul Ain Mustafa Muhammad Amir Muhammad Tanvir Sajid Zujaja Hina Haroon Aamir Ejaz Naveed Asif
author_sort	Qurat Ul Ain Mustafa
title	DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
title_short	DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
title_full	DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
title_fullStr	DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
title_full_unstemmed	DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS
title_sort	determination of frequency of a novel diagnostic category of hyperglycemia i.e. impaired random glucose in previously unknown patients of prediabetes and diabetes mellitus
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71iSuppl-1.3230 https://doaj.org/article/a0ba260ca1ad4feb86009e26292d9a00
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DETERMINATION OF FREQUENCY OF A NOVEL DIAGNOSTIC CATEGORY OF HYPERGLYCEMIA I.E. IMPAIRED RANDOM GLUCOSE IN PREVIOUSLY UNKNOWN PATIENTS OF PREDIABETES AND DIABETES MELLITUS

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