Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia
Abstract It is well documented that microgravity in space environment leads to bone loss in astronauts. These physiological changes have also been validated by human and animal studies and modeled in cell-based analogs. However, the underlying mechanisms are elusive. In the current study, we identif...
Guardado en:
Autores principales: | Wengui Shi, Yanfang Xie, Jinpeng He, Jian Zhou, Yuhai Gao, Wenjun Wei, Nan Ding, Huiping Ma, Cory J. Xian, Keming Chen, Jufang Wang |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a0be59ecfd824f6e9e318cb14dc4d29a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Combined Effects of Proton Radiation and Simulated Microgravity on the Cell Viability and ALP Activity of Murine Osteoblast Cells
por: Liqiu Ma, et al.
Publicado: (2021) -
Cilia
Publicado: (2012) -
Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material
por: Zhiwei Wang, et al.
Publicado: (2017) -
DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia
por: Jie Ding, et al.
Publicado: (2017) -
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer
por: Junguee Lee, et al.
Publicado: (2021)