Hierarchical control of enzymatic actuators using DNA-based switchable memories

Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.

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Autores principales:	Lenny H. H. Meijer, Alex Joesaar, Erik Steur, Wouter Engelen, Rutger A. van Santen, Maarten Merkx, Tom F. A. de Greef
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0c209b4d05a45be9da69efaa3c73650
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spelling	oai:doaj.org-article:a0c209b4d05a45be9da69efaa3c736502021-12-02T15:38:57ZHierarchical control of enzymatic actuators using DNA-based switchable memories10.1038/s41467-017-01127-w2041-1723https://doaj.org/article/a0c209b4d05a45be9da69efaa3c736502017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01127-whttps://doaj.org/toc/2041-1723Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.Lenny H. H. MeijerAlex JoesaarErik SteurWouter EngelenRutger A. van SantenMaarten MerkxTom F. A. de GreefNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lenny H. H. Meijer Alex Joesaar Erik Steur Wouter Engelen Rutger A. van Santen Maarten Merkx Tom F. A. de Greef Hierarchical control of enzymatic actuators using DNA-based switchable memories
description	Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.
format	article
author	Lenny H. H. Meijer Alex Joesaar Erik Steur Wouter Engelen Rutger A. van Santen Maarten Merkx Tom F. A. de Greef
author_facet	Lenny H. H. Meijer Alex Joesaar Erik Steur Wouter Engelen Rutger A. van Santen Maarten Merkx Tom F. A. de Greef
author_sort	Lenny H. H. Meijer
title	Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_short	Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_full	Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_fullStr	Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_full_unstemmed	Hierarchical control of enzymatic actuators using DNA-based switchable memories
title_sort	hierarchical control of enzymatic actuators using dna-based switchable memories
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0c209b4d05a45be9da69efaa3c73650
work_keys_str_mv	AT lennyhhmeijer hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT alexjoesaar hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT eriksteur hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT wouterengelen hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT rutgeravansanten hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT maartenmerkx hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories AT tomfadegreef hierarchicalcontrolofenzymaticactuatorsusingdnabasedswitchablememories
_version_	1718386006795747328

Hierarchical control of enzymatic actuators using DNA-based switchable memories

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