High drug-loading nanomedicines: progress, current status, and prospects

Shihong Shen, Youshen Wu, Yongchun Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China Abstract: Drug molecules transformed int...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shen SH, Wu YS, Liu YC, Wu DC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nanomedicines nanocarriers high drug-loading fabrication strategy optimum proposal Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a0c2acba21f04f3a8e6742c451ea5b70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a0c2acba21f04f3a8e6742c451ea5b70
record_format	dspace
spelling	oai:doaj.org-article:a0c2acba21f04f3a8e6742c451ea5b702021-12-02T02:10:34ZHigh drug-loading nanomedicines: progress, current status, and prospects1178-2013https://doaj.org/article/a0c2acba21f04f3a8e6742c451ea5b702017-05-01T00:00:00Zhttps://www.dovepress.com/high-drug-loading-nanomedicines-progress-current-status-and-prospects-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shihong Shen, Youshen Wu, Yongchun Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China Abstract: Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines. Keywords: nanomedicines, nanocarriers, high drug loading, fabrication strategy, optimum proposalShen SHWu YSLiu YCWu DCDove Medical Pressarticlenanomedicinesnanocarriershigh drug-loadingfabrication strategyoptimum proposalMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4085-4109 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicines nanocarriers high drug-loading fabrication strategy optimum proposal Medicine (General) R5-920
spellingShingle	nanomedicines nanocarriers high drug-loading fabrication strategy optimum proposal Medicine (General) R5-920 Shen SH Wu YS Liu YC Wu DC High drug-loading nanomedicines: progress, current status, and prospects
description	Shihong Shen, Youshen Wu, Yongchun Liu, Daocheng Wu Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China Abstract: Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines. Keywords: nanomedicines, nanocarriers, high drug loading, fabrication strategy, optimum proposal
format	article
author	Shen SH Wu YS Liu YC Wu DC
author_facet	Shen SH Wu YS Liu YC Wu DC
author_sort	Shen SH
title	High drug-loading nanomedicines: progress, current status, and prospects
title_short	High drug-loading nanomedicines: progress, current status, and prospects
title_full	High drug-loading nanomedicines: progress, current status, and prospects
title_fullStr	High drug-loading nanomedicines: progress, current status, and prospects
title_full_unstemmed	High drug-loading nanomedicines: progress, current status, and prospects
title_sort	high drug-loading nanomedicines: progress, current status, and prospects
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a0c2acba21f04f3a8e6742c451ea5b70
work_keys_str_mv	AT shensh highdrugloadingnanomedicinesprogresscurrentstatusandprospects AT wuys highdrugloadingnanomedicinesprogresscurrentstatusandprospects AT liuyc highdrugloadingnanomedicinesprogresscurrentstatusandprospects AT wudc highdrugloadingnanomedicinesprogresscurrentstatusandprospects
_version_	1718402665217523712

High drug-loading nanomedicines: progress, current status, and prospects

Ejemplares similares