Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.

Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep...

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Autores principales:	Nadja Strandberg Kristensen, Emma Hertel, Camilla Hoffmeyer Skadhauge, Sissel Højsted Kronborg, Kristian Kjær Petersen, Megan E McPhee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0c635bd9f8d43f0be1edfb1aa15ff37
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spelling	oai:doaj.org-article:a0c635bd9f8d43f0be1edfb1aa15ff372021-12-02T20:08:51ZPsychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.1932-620310.1371/journal.pone.0253945https://doaj.org/article/a0c635bd9f8d43f0be1edfb1aa15ff372021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253945https://doaj.org/toc/1932-6203Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep quality, physical activity, affective state, pain catastrophizing and psychophysical pain sensitivity have all been suggested to be involved. This study aimed to investigate whether factors at baseline could predict musculoskeletal pain intensity to an experimental delayed onset of muscle soreness (DOMS) pain model. Demographics, physical activity, pain catastrophizing, affective state, sleep quality, isometric force production, temporal summation of pain, and psychophysical pain sensitivity using handheld and cuff algometry were assessed at baseline (Day-0) and two days after (Day-2) in 28 healthy participants. DOMS was induced on Day-0 by completing eccentric calf raises on the non-dominant leg to fatigue. On Day-2, participants rated pain on muscle contraction (visual analogue scale, VAS, 0-10cm) and function (Likert scale, 0-6). DOMS resulted in non-dominant calf pain at Day-2 (3.0±2.3cm), with significantly reduced isometric force production (P<0.043) and handheld pressure pain thresholds (P<0.010) at Day-2 compared to Day-0. Linear regression models using backward selection predicted from 39.3% (P<0.003) of VAS to 57.7% (P<0.001) of Likert score variation in DOMS pain intensity and consistently included cuff pressure pain tolerance threshold (P<0.01), temporal summation of pain (P<0.04), and age (P<0.02) as independent predictive factors. The findings indicate that age, psychological and central pain mechanistic factors are consistently associated with pain following acute muscle injury.Nadja Strandberg KristensenEmma HertelCamilla Hoffmeyer SkadhaugeSissel Højsted KronborgKristian Kjær PetersenMegan E McPheePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadja Strandberg Kristensen Emma Hertel Camilla Hoffmeyer Skadhauge Sissel Højsted Kronborg Kristian Kjær Petersen Megan E McPhee Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
description	Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep quality, physical activity, affective state, pain catastrophizing and psychophysical pain sensitivity have all been suggested to be involved. This study aimed to investigate whether factors at baseline could predict musculoskeletal pain intensity to an experimental delayed onset of muscle soreness (DOMS) pain model. Demographics, physical activity, pain catastrophizing, affective state, sleep quality, isometric force production, temporal summation of pain, and psychophysical pain sensitivity using handheld and cuff algometry were assessed at baseline (Day-0) and two days after (Day-2) in 28 healthy participants. DOMS was induced on Day-0 by completing eccentric calf raises on the non-dominant leg to fatigue. On Day-2, participants rated pain on muscle contraction (visual analogue scale, VAS, 0-10cm) and function (Likert scale, 0-6). DOMS resulted in non-dominant calf pain at Day-2 (3.0±2.3cm), with significantly reduced isometric force production (P<0.043) and handheld pressure pain thresholds (P<0.010) at Day-2 compared to Day-0. Linear regression models using backward selection predicted from 39.3% (P<0.003) of VAS to 57.7% (P<0.001) of Likert score variation in DOMS pain intensity and consistently included cuff pressure pain tolerance threshold (P<0.01), temporal summation of pain (P<0.04), and age (P<0.02) as independent predictive factors. The findings indicate that age, psychological and central pain mechanistic factors are consistently associated with pain following acute muscle injury.
format	article
author	Nadja Strandberg Kristensen Emma Hertel Camilla Hoffmeyer Skadhauge Sissel Højsted Kronborg Kristian Kjær Petersen Megan E McPhee
author_facet	Nadja Strandberg Kristensen Emma Hertel Camilla Hoffmeyer Skadhauge Sissel Højsted Kronborg Kristian Kjær Petersen Megan E McPhee
author_sort	Nadja Strandberg Kristensen
title	Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
title_short	Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
title_full	Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
title_fullStr	Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
title_full_unstemmed	Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
title_sort	psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a0c635bd9f8d43f0be1edfb1aa15ff37
work_keys_str_mv	AT nadjastrandbergkristensen psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise AT emmahertel psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise AT camillahoffmeyerskadhauge psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise AT sisselhøjstedkronborg psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise AT kristiankjærpetersen psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise AT meganemcphee psychophysicalpredictorsofexperimentalmusclepainintensityfollowingfatiguingcalfexercise
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Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.

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