Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes

Abstract The purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly in...

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Autores principales:	Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a0c740802cf047938ba7c48cf8ac8631
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spelling	oai:doaj.org-article:a0c740802cf047938ba7c48cf8ac86312021-12-02T11:42:15ZRelationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes10.1038/s41598-020-77584-z2045-2322https://doaj.org/article/a0c740802cf047938ba7c48cf8ac86312020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77584-zhttps://doaj.org/toc/2045-2322Abstract The purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly increased levels of the plasma GDF-15 were found in individuals with diabetic retinopathy versus those without. According to the degree of diabetic retinopathy, there was a significant difference in the average plasma GDF-15 levels (no diabetic retinopathy, 1114 ng/L; nonproliferative diabetic retinopathy, 1327 ng/L; proliferative diabetic retinopathy, 1445 ng/L; p for trend = 0.035) after adjustments for confounders. Logistic regression analyses indicated that plasma GDF-15 concentrations were significantly associated with diabetic retinopathy (odds ratio per 1 standard deviation increment in the log-transformed value, 1.78; 95% confidence interval, 1.05–3.03, p = 0.032). Our study showed a significant positive relationship between plasma GDF-15 concentrations and diabetic retinopathy in type 2 DM patients.Jin Ook ChungSeon-Young ParkDong Hyeok ChoDong Jin ChungMin Young ChungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
description	Abstract The purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly increased levels of the plasma GDF-15 were found in individuals with diabetic retinopathy versus those without. According to the degree of diabetic retinopathy, there was a significant difference in the average plasma GDF-15 levels (no diabetic retinopathy, 1114 ng/L; nonproliferative diabetic retinopathy, 1327 ng/L; proliferative diabetic retinopathy, 1445 ng/L; p for trend = 0.035) after adjustments for confounders. Logistic regression analyses indicated that plasma GDF-15 concentrations were significantly associated with diabetic retinopathy (odds ratio per 1 standard deviation increment in the log-transformed value, 1.78; 95% confidence interval, 1.05–3.03, p = 0.032). Our study showed a significant positive relationship between plasma GDF-15 concentrations and diabetic retinopathy in type 2 DM patients.
format	article
author	Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung
author_facet	Jin Ook Chung Seon-Young Park Dong Hyeok Cho Dong Jin Chung Min Young Chung
author_sort	Jin Ook Chung
title	Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
title_short	Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
title_full	Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
title_fullStr	Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
title_full_unstemmed	Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
title_sort	relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a0c740802cf047938ba7c48cf8ac8631
work_keys_str_mv	AT jinookchung relationshipbetweenplasmagrowthdifferentiationfactor15levelsanddiabeticretinopathyinindividualswithtype2diabetes AT seonyoungpark relationshipbetweenplasmagrowthdifferentiationfactor15levelsanddiabeticretinopathyinindividualswithtype2diabetes AT donghyeokcho relationshipbetweenplasmagrowthdifferentiationfactor15levelsanddiabeticretinopathyinindividualswithtype2diabetes AT dongjinchung relationshipbetweenplasmagrowthdifferentiationfactor15levelsanddiabeticretinopathyinindividualswithtype2diabetes AT minyoungchung relationshipbetweenplasmagrowthdifferentiationfactor15levelsanddiabeticretinopathyinindividualswithtype2diabetes
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Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes

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