Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes

Abstract Plazomicin is currently the only next-generation aminoglycoside approved for clinical use that has the potential of evading the effects of widespread enzymatic resistance factors. However, plazomicin is still susceptible to the action of the resistance enzyme AAC(2′)-Ia from Providencia stu...

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Autores principales: Angelia V. Bassenden, Linda Dumalo, Jaeok Park, Jonathan Blanchet, Krishnagopal Maiti, Dev P. Arya, Albert M. Berghuis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a0c86b251ae74d7bb3c137708fa1bbd2
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