LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY

VEGF-A contents was studied in blood serum, lacrimal fluid, and vitreous body of patients with different clinical forms of complicated proliferative diabetic retinopathy (PDR). The study included 50 patients with diabetes mellitus (type I, II), twelve patients with rhegmatogenous retinal detachment...

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Autores principales:	V. V. Neroev, O. V. Zaytseva, N. V. Balatskaya, Z. V. Kurchaeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	proliferative diabetic retinopathy pathogenesis vitreoretinal surgery vegf-a Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a0cab521eb054b28bb1f23ef8cfe77fa
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spelling	oai:doaj.org-article:a0cab521eb054b28bb1f23ef8cfe77fa2021-11-18T08:03:45ZLOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY1563-06252313-741X10.15789/1563-0625-2016-4-357-364https://doaj.org/article/a0cab521eb054b28bb1f23ef8cfe77fa2016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1058https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XVEGF-A contents was studied in blood serum, lacrimal fluid, and vitreous body of patients with different clinical forms of complicated proliferative diabetic retinopathy (PDR). The study included 50 patients with diabetes mellitus (type I, II), twelve patients with rhegmatogenous retinal detachment and fifteen healthy individuals. Complicated PDR was shown to be associated with higher levels of VEGF-A in blood serum and lacrimal fluid of these patients as compared to the cases of stable PDR and healthy individuals, as well as increased VEGF-A concentrations in vitreous humor. Concentrations of this cytokine in vitreous body proved to be significantly exceeded those in rhegmatogenous retinal detachment. Most severe clinical manifestations in complicated PDR and intraoperative hemorrhagic complications were associated with sharp VEGF-A increase in blood serum and vitreous humor, thus reflecting certain disturbances at local and systemic levels.V. V. NeroevO. V. ZaytsevaN. V. BalatskayaZ. V. KurchaevaSPb RAACIarticleproliferative diabetic retinopathypathogenesisvitreoretinal surgeryvegf-aImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 4, Pp 357-364 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	proliferative diabetic retinopathy pathogenesis vitreoretinal surgery vegf-a Immunologic diseases. Allergy RC581-607
spellingShingle	proliferative diabetic retinopathy pathogenesis vitreoretinal surgery vegf-a Immunologic diseases. Allergy RC581-607 V. V. Neroev O. V. Zaytseva N. V. Balatskaya Z. V. Kurchaeva LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
description	VEGF-A contents was studied in blood serum, lacrimal fluid, and vitreous body of patients with different clinical forms of complicated proliferative diabetic retinopathy (PDR). The study included 50 patients with diabetes mellitus (type I, II), twelve patients with rhegmatogenous retinal detachment and fifteen healthy individuals. Complicated PDR was shown to be associated with higher levels of VEGF-A in blood serum and lacrimal fluid of these patients as compared to the cases of stable PDR and healthy individuals, as well as increased VEGF-A concentrations in vitreous humor. Concentrations of this cytokine in vitreous body proved to be significantly exceeded those in rhegmatogenous retinal detachment. Most severe clinical manifestations in complicated PDR and intraoperative hemorrhagic complications were associated with sharp VEGF-A increase in blood serum and vitreous humor, thus reflecting certain disturbances at local and systemic levels.
format	article
author	V. V. Neroev O. V. Zaytseva N. V. Balatskaya Z. V. Kurchaeva
author_facet	V. V. Neroev O. V. Zaytseva N. V. Balatskaya Z. V. Kurchaeva
author_sort	V. V. Neroev
title	LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
title_short	LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
title_full	LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
title_fullStr	LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
title_full_unstemmed	LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY
title_sort	local and systemic vegf-а production in complicated proliferative diabetic retinopathy
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/a0cab521eb054b28bb1f23ef8cfe77fa
work_keys_str_mv	AT vvneroev localandsystemicvegfaproductionincomplicatedproliferativediabeticretinopathy AT ovzaytseva localandsystemicvegfaproductionincomplicatedproliferativediabeticretinopathy AT nvbalatskaya localandsystemicvegfaproductionincomplicatedproliferativediabeticretinopathy AT zvkurchaeva localandsystemicvegfaproductionincomplicatedproliferativediabeticretinopathy
_version_	1718422438807601152

LOCAL AND SYSTEMIC VEGF-А PRODUCTION IN COMPLICATED PROLIFERATIVE DIABETIC RETINOPATHY

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