Overexpression of <i>Plasmodium falciparum</i> M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development

Overexpression of <i>Plasmodium falciparum</i> M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development

<i>Plasmodium falciparum</i>, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavage, an essential process for par...

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Autores principales: Carolina C. Hoff, Mauro F. Azevedo, Adriana B. Thurler, Sarah El Chamy Maluf, Pollyana M. S. Melo, Maday Alonso del Rivero, Jorge González-Bacerio, Adriana K. Carmona, Alexandre Budu, Marcos L. Gazarini
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>Plasmodium falciparum</i>
malaria
M1 alanyl-aminopeptidase
antimalarial
PfA-M1 overexpression
Medicine
R
Acceso en línea:https://doaj.org/article/a0d20a6310e044c2a2d8837dadf331db
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