Three dimensional and microphysiological bone marrow models detect in vivo positive compounds

Abstract Micronucleus (MN) assessment is a valuable tool in safety assessment. However, several compounds are positive in the in vivo bone marrow (BM) MN assay but negative in vitro, reflecting that BM complexity is not recapitulated in vitro. Importantly, these compounds are not genotoxic; rather,...

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Bibliographic Details
Main Authors: Rhiannon David, Sarah Gee, Kainat Khan, Amy Wilson, Ann Doherty
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/a0d2a586f0fc4f4e9d2b85c530eb68b8
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