Pathomorphological diagnostics of chronic appendicitis (literature review)

The review is devoted to the problem of diagnostics and differential diagnostics of chronic appendicitis. As it is commonly known, the very existence of chronic appendicitis is still considered controversial. The article describes the current ideas on chronic appendicitis (primary, secondary, residu...

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Autores principales:	N. N. Dremina, I. A. Shurygina, A. I. Panasyuk, O. V. Kanya, M. G. Shurygin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	vcam icam e-sellectin chronic appendicitis differential diagnosis Science Q
Acceso en línea:	https://doaj.org/article/a0d33d373a164138b0dc0951e07154a1
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spelling	oai:doaj.org-article:a0d33d373a164138b0dc0951e07154a12021-11-23T06:14:39ZPathomorphological diagnostics of chronic appendicitis (literature review)2541-94202587-959610.12737/article_5a3a0dda34db64.80244378https://doaj.org/article/a0d33d373a164138b0dc0951e07154a12017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/511https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The review is devoted to the problem of diagnostics and differential diagnostics of chronic appendicitis. As it is commonly known, the very existence of chronic appendicitis is still considered controversial. The article describes the current ideas on chronic appendicitis (primary, secondary, residual and recurrent), presents the list of morphological manifestations in the vermiform appendix at chronic inflammation, discovered at routine histological examination: dystrophic changes in the form of atrophy of all layers of appendix with sclerosis or hypotrophy of various degree, up to appendiclausis and disappearance of mucous membrane, and lipomatosis of submucosa. The authors discuss the complexity of diagnostics predetermined by lack of precise criteria of the disease; show the possibility of evaluation of the expression of cytoadherence molecules for diagnostics of the disease, in particular of VCAM-1 and ICAM-1 for differential diagnostics of chronic appendicitis. The role of suppressor of signal cytokine proteins SOCS3 in chronic inflammation is discussed. The data demonstrate the increase of T-lymphocytes and neurons in chronic appendicitis as an increase of PGP 9.5 (panneuronal marker protein gene product 9.5) level. It has been shown, that immunohistochemical staining on p44 MAPK has an advantage in differential diagnostics of chronic appendicitis - specific staining of subserous and muscle layer of the wall is observed only at the discussed pathology of the appendix. In spite of multiple studies and acknowledgment of the fact that chronic form of appendicitis is a separate disease, the diagnostics of this pathology still presents quite a problem especially when only routine methods of examination are used. Thus, we found it necessary to introduce additional immunomorphologic methods into the clinical practice.N. N. DreminaI. A. ShuryginaA. I. PanasyukO. V. KanyaM. G. ShuryginScientific Сentre for Family Health and Human Reproduction Problemsarticlevcamicame-sellectinchronic appendicitisdifferential diagnosisvcamicame-sellectinScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(2), Pp 74-77 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	vcam icam e-sellectin chronic appendicitis differential diagnosis vcam icam e-sellectin Science Q
spellingShingle	vcam icam e-sellectin chronic appendicitis differential diagnosis vcam icam e-sellectin Science Q N. N. Dremina I. A. Shurygina A. I. Panasyuk O. V. Kanya M. G. Shurygin Pathomorphological diagnostics of chronic appendicitis (literature review)
description	The review is devoted to the problem of diagnostics and differential diagnostics of chronic appendicitis. As it is commonly known, the very existence of chronic appendicitis is still considered controversial. The article describes the current ideas on chronic appendicitis (primary, secondary, residual and recurrent), presents the list of morphological manifestations in the vermiform appendix at chronic inflammation, discovered at routine histological examination: dystrophic changes in the form of atrophy of all layers of appendix with sclerosis or hypotrophy of various degree, up to appendiclausis and disappearance of mucous membrane, and lipomatosis of submucosa. The authors discuss the complexity of diagnostics predetermined by lack of precise criteria of the disease; show the possibility of evaluation of the expression of cytoadherence molecules for diagnostics of the disease, in particular of VCAM-1 and ICAM-1 for differential diagnostics of chronic appendicitis. The role of suppressor of signal cytokine proteins SOCS3 in chronic inflammation is discussed. The data demonstrate the increase of T-lymphocytes and neurons in chronic appendicitis as an increase of PGP 9.5 (panneuronal marker protein gene product 9.5) level. It has been shown, that immunohistochemical staining on p44 MAPK has an advantage in differential diagnostics of chronic appendicitis - specific staining of subserous and muscle layer of the wall is observed only at the discussed pathology of the appendix. In spite of multiple studies and acknowledgment of the fact that chronic form of appendicitis is a separate disease, the diagnostics of this pathology still presents quite a problem especially when only routine methods of examination are used. Thus, we found it necessary to introduce additional immunomorphologic methods into the clinical practice.
format	article
author	N. N. Dremina I. A. Shurygina A. I. Panasyuk O. V. Kanya M. G. Shurygin
author_facet	N. N. Dremina I. A. Shurygina A. I. Panasyuk O. V. Kanya M. G. Shurygin
author_sort	N. N. Dremina
title	Pathomorphological diagnostics of chronic appendicitis (literature review)
title_short	Pathomorphological diagnostics of chronic appendicitis (literature review)
title_full	Pathomorphological diagnostics of chronic appendicitis (literature review)
title_fullStr	Pathomorphological diagnostics of chronic appendicitis (literature review)
title_full_unstemmed	Pathomorphological diagnostics of chronic appendicitis (literature review)
title_sort	pathomorphological diagnostics of chronic appendicitis (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/a0d33d373a164138b0dc0951e07154a1
work_keys_str_mv	AT nndremina pathomorphologicaldiagnosticsofchronicappendicitisliteraturereview AT iashurygina pathomorphologicaldiagnosticsofchronicappendicitisliteraturereview AT aipanasyuk pathomorphologicaldiagnosticsofchronicappendicitisliteraturereview AT ovkanya pathomorphologicaldiagnosticsofchronicappendicitisliteraturereview AT mgshurygin pathomorphologicaldiagnosticsofchronicappendicitisliteraturereview
_version_	1718416964645289984

Pathomorphological diagnostics of chronic appendicitis (literature review)

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